background & aim:breast cancer is the second most common cancer in women after lung cancer. given that the herbal ingredients are used for centuries to treat cancer,the aim of this study was to determine the cytotoxic effect of hydroalcholic extract from thymus daenesiscelak on mcf-7 cancer cells line. experimental: breast cancer cells mcf-7 and natural fibroblast cells were cultured in dmem me...

Melatonin is a hormone that exhibits many bioactivities such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, neuroprotective, and anti-aging activity. In addition, melatonin has been used to strengthen the effect of drugs or agents for treatment in different disease models cancer, tumor, bacterial infection, autoimmune diseases, gastrointestinal diseases. According recent s...

The cGAS/STING signaling pathway plays a pivotal role in regulating innate immunity. Emerging novel drugs aim to regulate the anti-tumor immune response by activating anti-diabetic drug metformin has been reported exhibit anti-cancer effect against various types of cancer. However, gastric cancer remains unknown. In our study, we first used bioinformatic analysis detect that is closely related ...

Breast cancer is the most prevalent malignancy in women throughout the world. Similar to other cancers, a strong relationship between breast cancer and environmental factors such as infectious agents has been reported. Toxoplasma gondii is a protozoan parasite which may play a role in cancer induction. The present study aimed to investigate a possible association between a history of T. gondii ...

Cardiovascular disease arises from known cardiac side effects of several anti-cancer therapies, but also cancer itself promotes cardiovascular disease. On the other hand, diseases predispose to future development cancer.

Prostate cancer is a devastating disease for which current therapies are inadequate. Various lines of evidences have suggested the 5-lipoxygenase (5-LOX) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of Prostate cancer. Thus, search for new anti-cancer drugs targeting 5-LOX and leukotriene is very essential and important. The objective of the pre...

Several dietary and medicinal herbs have been shown to be effective in the treatment prevention of cancer. Although Piper nigrum has anti-cancer activities against various cancer cells, its anti-pancreatic properties not reported. In present study, P. extract (PNE) inhibited proliferation PANC-1 human pancreatic cells. Flow cytometry showed G0/G1 arrest caused by PNE addition, Western blot anal...

compared to western countries, pancreatic cancer has a relatively low incidence in iran. it is rarely diagnosed before the fifth decade in iran and most of the patients are older than 60 at the time of diagnosis like to the western countries, where pancreatic cancer is a disease of advanced age. the incidence of the disease in some young patients suggests a possible role of genetic defects, whi...

objective: immunotoxins (its) have been developed for the treatment of cancer, and comprise of antibodies linked to toxins. also vascular endothelial growth factor (vegf) plays a key role in tumor angiogenesis, and the blockade of vegf receptor-2 (vegfr2) inhibits angiogenesis and tumor growth. the aim of this study was to produce anti-vegfr2/rpe (pseudomonas exotoxin) 38 it to test its cytotox...