The global burden of antibiotic resistance is tremendous and, without new anti-infective strategies, will continue to increase in the coming decades. Despite the growing need for new antibiotics, few pharmaceutical companies today retain active antibacterial drug discovery programmes. One reason is that it is scientifically challenging to discover new antibiotics that are active against the ant...

Many publications in the past 10 years have emphasised the difficulties of evaluating anti-infective drugs and the need for well-designed clinical trials in this therapeutic field. The clinical development of sparfloxacin in Europe, involving more than 4000 patients in ten countries, provided the opportunity to implement a methodology for evaluation and statistical analyses which would take int...

In the UK Government's 1993 review of science and technology the statement is made that "the interval between scientific discovery and practical application is diminishing".' Two changes might explain such an acceleration of the acceptance of scientific innovation. Alterations may have occurred in the way that scientific ideas are spread, with concomitant increases in their rates of diffusion. ...

glycyrrhiza glabra,  family leguminoseae, is a plant which grows  in egypt and  other  countries  of  the world.  its  roots  possess  some  nutritive  value and medicinal properties. glycyrrhiza glabra linn, a commonly used herb in ayurvedic medicine. studies indicate that glycyrrhiza glabra linn possesses antibacterial, antioxidant, antimalerial, antispasmodic, anti-inflammatory and anti hype...

conclusions from the results, it was concluded that agricultural lands around pakistan council of scientific and industrial research (pcsir) campus lahore were rich sources of industrially important streptomyces, especially s. avermitilis. results the 10 selected isolates were identified as the avermectin-producing strain by fermentation and characterized on isp2 medium for aerial and reverse s...

Scientific investigations of medicinal plants have been initiated in many parts our country because their contribution to health care. The properties are due the presence phytochemicals. phytochemicals anti-oxidant and anti-microbial properties. resistance antibiotics by bacteria is increasingly becoming a concern public health. Currently used antibiotic agents fail bring an end bacterial infec...

context biocompatible polymers are potentially effective for dental infections as delivery carriers of disinfectants or antibiotics into the root canal system (rcs). this study aimed to review polymeric microspheres enabling a controlled release of endodontic medicaments. evidence acquisition a literature search was carried out in the pubmed database (may 2013) using the following keywords: “po...

Sulphonamides are the first effective chemotherapeutic agents used for bacterial infection in humans. Sulfonamides have a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, anti retroviral, anti cancer, antiinflammatory, and used as diuretic. This review consists of a discussion on the...