In spite of significant progress in anti-HIV-1 therapy, current antiviral chemo-therapy still suffers from deleterious side effects and emerging drug resistance. Therefore, the development of novel antiviral drugs remains a crucial issue for the fight against AIDS. HIV-1 integrase is a key enzyme in the replication cycle of the retrovirus since it catalyzes the integration of the reverse transc...

BACKGROUND Hearing aids sold directly to consumers in retail stores or through the internet, without individual prescription by audiological professionals, are termed over-the-counter (OTC) devices. This study aimed to determine whether there was any change in the electroacoustic characteristics of OTC devices compared to research carried out a decade earlier. The previous results indicated tha...

It is believed that tuberculosis has been killing human beings for over 4000 years. Several reports exist of ancient Egyptian mummies having signs of tubercular decay in their bodies. After the discovery of powerful anti-TB drugs such as streptomycin, isoniazid and rifampin during 1940-70s, it was thought that TB would be gone from the face of the earth, but tuberculosis still remains one of th...

It is believed that tuberculosis has been killing human beings for over 4000 years. Several reports exist of ancient Egyptian mummies having signs of tubercular decay in their bodies. After the discovery of powerful anti-TB drugs such as streptomycin, isoniazid and rifampin during 1940-70s, it was thought that TB would be gone from the face of the earth, but tuberculosis still remains one of th...

The concept proposed by WHO of an essential drugs list that should comprise drugs corresponding to the health needs of the majority of the people has been embraced by countries, which have adapted it to their needs. In this study, the essential antibacterial drug lists of 16 countries chosen from the six WHO regions are reviewed. Most of these countries include 73% of WHO-recommended essential ...

introduction: post-endodontic pain is one of the main problems for both patients and dentists. the purpose of this study was to compare the effectiveness of premedication with indomethacin and ibuprofen for management of postoperative endodontic pain. methods and materials: in this clinical trial, mandibular molars with irreversible pulpitis were endodontically treated in 66 patients. the medic...

Over the last decade, there has been a steady increase in the use of fixed-dose combinations of drugs for the treatment of a range of diseases, including hypertension, cancer, AIDS, tuberculosis and other infectious diseases. It is now evident that patients with asthma or chronic obstructive pulmonary disease (COPD) can also benefit from the use of fixed-dose combinations, including combination...

There has been considerable interest in the development of new anti tubercular agents particularly against multidrug resistance and extensively drug resistant strain of tuberculosis because mycobacterium species have developed resistant against currently used drugs. The currently use antitubercular drugs having toxic effect and long period of therapeutic treatment. Therefore, many researchers h...

ABSTRACT This article aims to present the experience of implementing ‘Street Outreach Teams’ in city Recife-PE as a strategy for HIV/AIDS prevention and Harm Reduction (HR) associated with use alcohol, crack, other drugs. Although review history this process reveals tensions, volatility, alternations care models implemented by management, analysis points out importance reaffirming, current cont...