Although anterograde amnesia can occur after damage in various brain sites, hippocampal dysfunction is usually seen as the ultimate cause of the failure to learn new episodic information. This assumption is supported by anatomical evidence showing direct hippocampal connections with all other sites implicated in causing anterograde amnesia. Likewise, behavioural and clinical evidence would seem...

After hypoxia, a critical adverse outcome is the inability to create new memories. How anterograde amnesia develops or resolves remains elusive, but a link to brain-based IL-1 is suggested due to the vital role of IL-1 in both learning and brain injury. We examined memory formation in mice exposed to acute hypoxia. After reoxygenation, memory recall recovered faster than memory formation, impac...

ory was relatively intact. On discharge, Mr. A continued to show improvement in his cognitive functions, and 2 months after the onset of NMS, his score on MMSE was 25/30 with persistent deficits in immediate and recent memory. He still had retrograde amnesia about the events surrounding the NMS and also had anterograde amnesia with deficits in learning new verbal information. Again, no deficits...

We present a case of opioid-associated amnestic syndrome (OAS) in 46-year-old female with persistent acute anterograde amnesia and biochemically confirmed fentanyl use. The brain Magnetic Resonance Imaging (MRI) examination demonstrated symmetric restricted diffusion T2/fluid-attenuated inversion recovery (FLAIR) hyperintensities the hippocampi cerebellum. While cases cerebellar findings OAS ar...

A nonhuman primate model of the key cognitive effects of convulsive treatment was developed and tested. Rhesus macaques were trained on 3 tasks: a long-term memory task that required selection of a constant target from a background of distracters, an anterograde task that involved learning a new target each day against a variable number of distracters, and a task that assessed learning and memo...

Transient global amnesia (TGA) is a disorder characterized by a sudden attack of severe anterograde amnesia, where patients are unable to learn and recall novel information during the event. Although fi rst described at least 60 years ago, the etiology and pathophysiology of TGA remain unclear and have been a matter of debate among clinicians and researchers. In this paper, we present a case of...

BACKGROUND Some studies have shown the presence of psychopathological disorders in transient global amnesia. AIMS To determine whether transient global amnesia is associated with psychopathological disorders and to assess the influence of these psychopathological disorders on memory impairments. METHOD Levels of anxiety and depression before and during transient global amnesia were rated. M...

We report a case of a 55-year-old man with ischemic lesions of the bilateral hippocampus and bilateral basal ganglia following a myocardial infarction during an episode of multiple drug use with subsequent anoxia requiring resuscitation. He presented for a neuropsychological evaluation with an anterograde amnesia for both explicit and procedural memory. There are two main points to this case, t...

Psychiatric patients receiving a course of electroconvulsive therapy for relief of depressive illness were given a test of remote memory for public events covering the years 1940-1969. An impairment in remote memory, covering nearly the entire time period sampled by the test, developed during the tirst five treatments. This impairment was present during the first hour after the fifth treatment ...