Abstract Background Despite annexin A1 (ANXA1), an anti-inflammatory and pro-resolving protein, regulates the NLRP3 inflammasome activation in inflammatory cells, this relationship has not been explored bowel disease. Then, study evaluated expression patterns of ANXA1 Crohn's disease (CD). Methods Paraffin-embedded human intestine biopsies, obtained from CD (n=20) control (n=8) patients were pr...

Annexins are a well-known multigene family of Ca(2+)-regulated phospholipid-binding and membrane-binding proteins. Recent work employing annexin-knockdown or - knockout models has provided new insights into the biological functions of different annexin proteins. Transient annexin depletion by RNA interference and the expression of dominant-negative mutant proteins has revealed roles for the pro...

Inflammation is a body response towards any injury or tissue damage. It involves the accumulation of neutrophils and release inflammatory mediators. ANXA1, 37 kDa glucocorticoid inducible protein plays an important role in resolving inflammation. The unique N-terminal its mimetic peptide exert strong anti-inflammatory actions. This study was conducted to review roles ANXA1 inflammation identify...