The investigation of mouse flank tumours by magnetic resonance imaging (MRI) is limited by the achievable spatial resolution, which is generally limited by the critical problem of signal-to-noise ratio. Sensitivity was improved by using an optimized solenoid RF micro-coil, built into the animal cradle. This simple design did not require extensive RF engineering expertise to construct, yet allow...

BACKGROUND Synovial sarcoma represents one of the most frequent malignant tumours of soft tissues. Its prognosis is poor because of chemoresistance and high metastatic potential. Improvement of synovial sarcoma outcome requires well-characterized animal models in which to evaluate novel therapeutic options. The aim of this study was to establish a reproducible synovial sarcoma model in athymic ...

Inducing tumour-specific adaptive immunity, such as cytotoxic T lymphocyte (CTL) response, can result in promising antitumour effect against several human malignancies, especially in combination with immune checkpoint blockade strategies. However, little is known whether activation of innate immunity can lead to direct tumoricidal effect. Here, we develop a papilloma pseudovirus-based oral immu...

Research into heat shock proteins (HSPs) for the clinical management of tumours has intensified as new evidence shows they can be used as biomarkers in carcinogenesis and are related to poor prognosis in some cancer types. Members of small HSP, HSP70 and HSP90 families have been studied extensively in breast cancer. This article reviews current understanding of the role of HSP and HSF-1 (Heat s...

1,2 dimethylhydrazine (DMH) rat model has been proven to be a valuable animal model of colorectal cancer. Because of its morphological similarity to human colorectal cancer, DMH rat model was used to produce information in histology and biochemistry of tumours development as well as on factors that retard or enhance tumorigenesis. Nevertheless, it has been shown that DMH model has limitations, ...

Pituitary neoplasias can occur as part of a complex inherited disorder, or more commonly as sporadic (non-familial) disease. Studies of the molecular and genetic mechanisms causing such pituitary tumours have identified dysregulation of >35 genes, with many revealed by studies in mice, rats and zebrafish. Strategies used to generate these animal models have included gene knockout, gene knockin ...

Androgen receptor (AR) antagonist MDV3100 is the first therapeutic approach in treating castration-resistant prostate cancer (CRPC), but tumours frequently become drug resistant via multiple mechanisms including AR amplification and mutation. Here we identify the small molecule Ailanthone (AIL) as a potent inhibitor of both full-length AR (AR-FL) and constitutively active truncated AR splice va...

Gold is an excellent absorber of X-rays. If tumours could be loaded with gold, this would lead to a higher dose to the cancerous tissue compared with the dose received by normal tissue during a radiotherapy treatment. Calculations indicate that this dose enhancement can be significant, even 200% or greater. In this paper, the physical and biological parameters affecting this enhancement are dis...

118 WNT signalling and the initiation of CRC Around 70% of sporadic colorectal tumours show biallelic inactivation of the APC gene (Adenomatous polyposis Coli). A high percentage of remaining tumours show activating mutations in beta-catenin or axin. These molecules are components of the Wnt signalling pathway. Activating mutations of the Wntsignalling pathway are the only known genetic alterat...

meantime by Gye and Foulds ( 1) no observations on this animal have been recorded. We used the Syrian, or golden, hamster ( Cricctus auratus), of which one strain is bred in our laboratory. Animals weighing about 80 gm. were injected subcutaneously, in the abdominal region, with benzpyrene Meurice, 0.25 C.C. of a solution in lard, every three or four weeks, the injections being interrupted as s...