نتایج جستجو برای: angle glaucoma poag
تعداد نتایج: 146295 فیلتر نتایج به سال:
BACKGROUND Genome-wide association studies (GWAS) have identified association of common alleles with primary open-angle glaucoma (POAG) and its quantitative endophenotypes near numerous genes. This study aims to determine whether rare pathogenic variants in these disease-associated genes contribute to POAG. METHODS Participants fulfilled strict inclusion criteria of advanced POAG at a young a...
Objective This study determined the risk factors for primary open-angle glaucoma (POAG) among Filipinos. Methods This is a case-control study of POAG cases and controls recruited from the University of the Philippines-Philippine General Hospital (UP-PGH). All underwent a comprehensive eye examination consisting of best-corrected visual acuity, applanation tonometry, slitlamp biomicroscopy, goni...
Purpose Recent studies indicate that mitochondrial proteins may contribute to the pathogenesis of primary open-angle glaucoma (POAG). In this study, we examined the association between POAG and common variations in gene-encoding mitochondrial proteins. Methods We examined genetic data from 3430 POAG cases and 3108 controls derived from the combination of the GLAUGEN and NEIGHBOR studies. We c...
Introduction: Glaucoma is considered as a major cause of irreversible vision loss, worldwide. Glaucoma includes a diverse ophthalmopathies characterized by attenuating the neural and connective tissue segments and eventually progression of specific patterns of visual dysfunction. Currently, perimetry is known as the most accurate diagnostic method in glaucoma and its follow up...
What is the association between refractive error and glaucoma when race and ethnicity are factored in? Shen et al. explored this question and found that myopia and hyperopia are associated with particular forms of glaucoma. The investigators looked at primary angle-closure glaucoma (PACG) and 3 types of open-angle glaucoma: primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and ...
PURPOSE To assess the prevalence and mechanism of glaucoma in adults living in an urban area of southern China. METHODS Random clustering sampling was used to identify adults aged 50 years and over in Liwan District, Guangzhou. Glaucoma was diagnosed with the ISGEO (International Society of Geographical and Epidemiological Ophthalmology) classification scheme. All subjects underwent gonioscop...
Glaucoma is a leading cause of worldwide irreversible visual impairment and blindness and is a clinically and genetically heterogenous group of optic neuropathies. Specific mutations in the myocilin (MYOC) gene cause primary open angle glaucoma (POAG) with varying age-of-onset and degree of severity. We show a mutation-dependent, gain-of-function association between human myocilin and the perox...
PURPOSE To determine if nerve fiber layer thickness (NFLT) in glaucoma patients decreases before the development of visual field loss, and if there is a difference in the thinning of NFLT between primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) eyes. METHODS Thirty patients (33 eyes) with POAG and 31 patients (31eyes) with NTG, who had visual field defects localized in eit...
Asymmetric Patterns of Visual Field Defect in Primary Open-Angle and Primary Angle-Closure Glaucoma.
Purpose To compare the hemifield asymmetry of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) across all severity levels. Methods A total of 522 eyes of 327 patients with POAG (mean age ± SD, 54.1 ± 12.4 years) and 375 eyes of 204 patients with PACG (67.3 ± 8.9 years) were included. Subjects meeting the definitions of POAG or PACG were in...
Objective(s):Glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. In the present study, we examined the polymorphism of GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) in 100 Glaucoma patients (41with pr...
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