Endothelial nitric oxide synthase (eNOS) produces NO (and/or other reactive nitrogen species) in vascular endothelial cells and cardiomyocytes in response to a variety of agonists and mechanical stimuli (eg, stretch, shear). The central role of NO in the homeostatic balance of the healthy endothelium justifies a growing interest in the molecular mechanisms governing its production by eNOS in a ...

Background and Purpose—White matter hyperintensities (WMH) are highly heritable and associated with small artery ischemic stroke, so they may be a useful trait for studying the genetics of small vessel disease. Many studies have attempted to find associations between polymorphisms in various candidate genes and WMH. We aimed to evaluate the evidence for these associations by performing a system...

There is increasing evidence that conversion of angiotensin I into angiotensin I1 can occur in the renal vasculature of humans [l l , and in the vascular beds of the hind limb of the dog 121. In previous experiments the specific angiotensionconverting enzyme in rat aorta [31 has been demonstrated. More recently, Mizuno et al. [41 have studied the subcellular localization of the enzyme activity ...

mucopolysaccharidoses are a group of rare mostly autosomal recessive metabolic and genetic disorders. because of the high rate of consanguinity, they are not uncommon in our population. clinical diagnosis is not difficult for experienced physicians, but it is not enough for treatment and prevention measures in the future pregnancies. so, it is necessary to detect the type of mps by measurement ...

Introduction and objectives. Data on chronic anemia following heart transplantation (HT) are scarce and contradictory. Our aims were to determine the prevalence of chronic anemia after HT, to identify predisposing factors for the condition at 12 months, and to evaluate its influence on mediumterm and long-term survival. Methods. Retrospective analysis of patients who underwent HT between 1991 a...

To cite: Seedat A, Rowe C, Fallouh B. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013009125 DESCRIPTION An 81-year-old gentleman was referred to the medical team by his general practitioner (GP) with a biochemically worsening renal function. Medical history included hypertension, chronic kidney disease and a 67 pack-year smoking history. Significantly, there ...

INTRODUCTION Gynura procumbens has been shown to decrease blood pressure via inhibition of the angiotensinconverting enzyme. However, other mechanisms that may contribute to the hypotensive effect have not been studied. OBJECTIVES To investigate the cardiovascular effects of a butanolic fraction of Gynura procumbens in rats. METHODS Anaesthetized rats were given intravenous bolus injections...

Hospital Physician March 2007 11 C oronary artery disease (CAD) is the leading cause of death worldwide and in the United States, where it accounts for more than 494,000 deaths per year.1,2 Approximately 18% of patients with CAD present with sudden cardiac death as their first sign of disease.3 Disruption of plaque commonly causes acute coronary syndromes (ACS) and may result in death due to my...

Yamaleyeva LM, Gilliam-Davis S, Almeida I, Brosnihan KB, Lindsey SH, Chappell MC. Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Am J Physiol Renal Physiol 302: F1374–F1384, 2012. First published February 29, 2012; doi:10.1152/ajprenal.00656.2011.—We examined the impact of early diabetes on the circulating and kidney ren...

Patients aged 60 years and older with essential hypertension were treated with an angiotensinconverting enzyme inhibitor (ACE-I), delapril (Adecut) or a long-acting calcium (Ca)-antagonist, manidipine (Calslot) for 3 years. The incidences of cardiovascular events as well as drug-related side effects were compared between the two groups to investigate whether both classes of antihypertensive dru...