نتایج جستجو برای: angiogenic proteins

تعداد نتایج: 570154  

Journal: :Archivum immunologiae et therapiae experimentalis 1999
A Wiedłocha

Angiogenin is a potent inducer of new blood vessel formation. It binds to high-affinity endothelial cell-surface receptors and, with lower affinity, to extracellular matrix. Angiogenin is the only angiogenic factor known to exhibit ribonucleolytic activity. It belongs to the pancreatic RNase superfamily of proteins. Angiogenin is the only member of the superfamily able to stimulate angiogenesis...

2017
Pratiek N. Matkar Ramya Ariyagunarajah Howard Leong-Poi Krishna K. Singh

Angiogenesis, the formation of new blood vessels from pre-existing ones is a biological process that ensures an adequate blood flow is maintained to provide the cells with a sufficient supply of nutrients and oxygen within the body. Numerous soluble growth factors and inhibitors, cytokines, proteases as well as extracellular matrix proteins and adhesion molecules stringently regulate the multi-...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 1999
Michael K Jones Rabiha M Itani Hongtao Wang Morimasa Tomikawa I James Sarfeh Sandor Szabo Andrzej S Tarnawski

Our previous studies demonstrated that ethanol injury triggers the angiogenic response in gastric mucosa bordering necrosis. The present study was aimed to determine whether vascular endothelial growth factor (VEGF) (a potent angiogenic peptide selectively acting on endothelial cells) and Ras (a mediator of cell proliferation and a putative regulator of VEGF expression) are involved in gastric ...

2015
Jin-Mu Yi Ok-Sun Bang No Soo Kim

BACKGROUND Angiogenesis is a general hallmark of cancer; therefore, the inhibition of tumor-derived angiogenesis is considered to be an attractive target in the development of anti-cancer agents. Sa-mi-yeon-geon-tang (SMYGT), a decoction that consists of four natural medicinal products, has been traditionally prescribed in Oriental medicine to treat diverse diseases, including cancer. In the pr...

2016
Nicolas Marinval Pierre Saboural Oualid Haddad Murielle Maire Kevin Bassand Frederic Geinguenaud Nadia Djaker Khadija Ben Akrout Marc Lamy de la Chapelle Romain Robert Olivier Oudar Erwan Guyot Christelle Laguillier-Morizot Angela Sutton Cedric Chauvierre Frederic Chaubet Nathalie Charnaux Hanna Hlawaty

Herein we investigate the structure/function relationships of fucoidans from Ascophyllum nodosum to analyze their pro-angiogenic effect and cellular uptake in native and glycosaminoglycan-free (GAG-free) human endothelial cells (HUVECs). Fucoidans are marine sulfated polysaccharides, which act as glycosaminoglycans mimetics. We hypothesized that the size and sulfation rate of fucoidans influenc...

Journal: :Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2020

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد علوم دارویی - پژوهشکده علوم 1392

purpose a metabolic abnormality such as obesity is a major obstacle in the maintenance of the human health system and causes various chronic diseases including type 2 diabetes, hypertension, cardiovascular diseases, as well as various cancers. this study was designed to summarize the recent scientific knowledge regarding the anti-obesity role of curcumin (diferuloylmethane), which is isolated f...

Journal: :Advanced healthcare materials 2012
Daniel Rönnlund Yang Yang Hans Blom Gert Auer Jerker Widengren

Dysregulation of how platelets store, sequester and release specific proteins seems to be implicated in many disease states, including cancer. Dual-color immunofluorescence stimulated emission depletion (STED) microscopy with 40 nm resolution is used to map pro-angiogenic VEGF, anti-angiogenic PF-4 and fibrinogen in >300 individual platelets. This reveals that these proteins are stored in a seg...

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