Angiogenesis is a fundamental process in various physiologic and pathologic processes. The ability to visualize and quantify angiogenesis will allow early diagnosis and monitoring for clinical determination of angiogenesis states before, during, and after adjuvant antiangiogenic and therapeutic angiogenesis treatments.

Plasmin (Plm), a trypsin-like serine protease, is responsible for fibrinolysis pathway and pathologic events, such as angiogenesis, tumor invasion, metastasis, alters the expression of cytokines. A growing body data indicates that Plm inhibitor potential candidate an anti-inflammatory anti-cancer agent. class active site-directed plasmin inhibitors containing tranexamic acid residue has been de...