Prostate Cancer is the second most prevalent neoplasm after lung cancer in men. It commonly presents in patients with a strong family history. The measurement of Prostate Specific Antigen (PSA) in free and bound forms is one of the methods to diagnose it. It is very much useful for monitoring the therapeutic efficacy, staging, prognosis, tumour volume evaluation, detection of recurrent disease,...

Background/Aim: Head-and-neck squamous cell carcinoma (HNSCC) is the fifth most common cancer in world and human papillomavirus (HPV) an important risk factor for this neoplasm. Recent studies showed association between sex hormone receptors pathogenesis and/or prognosis patients with HNSCC. The aim of study was to clarify expression patterns HPV-positive HPV-negative HNSCC their associations t...

Approximately 7% of women of reproductive age manifest polycystic ovary syndrome (PCOS) and <0.5% have other causes of hyperandrogenism including congenital adrenal hyperplasia (CAH), androgen-secreting tumour of an ovary or an adrenal gland, Cushing's syndrome or hyperthecosis. The presence of features atypical of PCOS should prompt more extensive evaluation than that usually undertaken. Featu...

OBJECTIVES To review the literature and present new data of continuous androgen deprivation therapy (ADT) vs intermittent androgen deprivation (IAD) as therapies for prostate cancer in terms of survival and quality of life and clarify practical issues in the use of IAD. MATERIALS AND METHODS We conducted a systematic search on Medline and Embase databases using ″prostatic neoplasm″ and ″inter...

Most authors agree with the subdivision of the broad general group into two main types : (1) the cylindroid, or cylindromatous form; (2) the carcinoid form. Considering the large number of bronchial adenomas reported, it is surprising to find only a few with distant or disseminated metastases. Survey of the available literature reveals that the adenomas producing distant metastases have been al...

The demonstration by Mortimer et al. (1986a; this issue, p. 263) that hidradenitis suppurativa responded to treatment with the antiandrogen cyproterone acetate, in a meticulously assessed double-blind trial, substantiates the view that the condition is androgen-dependent. Such a hypothesis was first advanced in the anecdotal report (Ebling et al, 1979) referred to by Mortimer et al, and details...

Kaposi's sarcoma (KS) develops in a variety of clinical states and is the most common tumor seen in patients with HIV-1 infection. KS develops as a multifocal mucocutaneous disease with subsequent spread to visceral organs, and it has been argued to be a benign proliferation caused by its multifocality at initial presentation, lack of aneuploidy, and spontaneous regression upon withdrawal of im...