background and aims. the role of cytokines in the immunopathogenesis of oral lichen planus (olp) has received much attention. the aim of this study was to evaluate the serum levels of tnf-α and tgf-β in patients with olp in an iranian population. materials and methods. thirty-two patients with olp and 32 age-matched healthy volunteers as a control group were included in this study. serum tests ...

background host genetic and environmental factors are involved in development of gastric cancer. tumor necrosis factor (tnf)-î±| has a key role in helicobacter pylori -induced gastritis. we analyzed the association between tnf-î± polymorphism and the risk of gastric cancer in an iranian population residing in northeastern iran. materials and methods in a case-control study, the genotyping was c...

the present study aimed at evaluating the effect of aerobic exercise in carbon black particulates air pollution on tlr4 and tnf-α gene expression in male rats. 24 male wistar rats (mean body mass 279.29+26.97 gr) were randomly divided into 4 groups: a) control, b) aerobic exercise, c) pollution, d) exercise+pollution. a particulates injector and falounak chamber were used to expose the rats to ...

background: we investigated the effects of withania somnifera root (ws) on insulin resistance, tumor necrosis factor α (tnf-α), and interleukin-6 (il-6) in fructose-fed rats. methods: forty-eight wistar-albino male rats were randomly divided into four groups (n=12); group i as control, group ii as sham-treated with ws by 62.5mg/g per diet, group iii fructose-fed rats received 10%w/v fructose, a...

background and aim: vitamin d has immune-regulatory functions in experimental inflammatory bowel disease (ibd) and vitamin d deficiency is common in ibd patients. the aim of the study was to assess the effectiveness of vitamin d 3 [1,25(oh) 2 d 3 ] treatment in ibd with regard to tumor necrosis factor-alpha (tnf-?) serum level and  clinical disease activity index (cdai). materials and methods: ...

background: preeclampsia is a disorder unique to pregnancy and has long been recognized as an important contributor of maternal and fetal morbidity and mortality. it is suggested that cytokines such as tumor necrosis factor-alpha (tnf-α) have an important role in the pathogenesis of preeclampsia and may cause generalized endothelial dysfunction. objective: the aim of this study was comparison o...

rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. several studies in recent years were conducted for evaluation of inflammatory cytokines such as il1-α (interlukin 1α) and tnf- α (tumor necrosis factor) in rheumatologic disorders including rheumatoid arthrit...