It has been revealed that the function of transmembrane (TM) proteins (20-30% in most genomes [1]) can be classified and identified with the information of its TM topologies, i.e., the number of TM segments (TMSs), the position of TMS and the orientation of the TMS to the membrane lipid bilayer [6]. Therefore, developing the TM topology prediction method with high reliability is critical task f...

The purpose of this study was to investigate whether the practice of the Transcendental Meditation (TM) and TM-Sidhi program influences cognitive-moral development. Seventy-six undergraduate students, ranging in age from 16 to 23 years, participated in the study: I7 students from Roger Williams College, Rhode Island, who were not predisposed to starting the TM program (nonmeditators); I2 studen...

Let TM(k, l) be the set of one-tape Turing machines with k states and l symbols. It is known that the halting problem is decidable for machines in TM(2, 3) and TM(3, 2). We prove that the decidability of machines in TM(2, 4) and TM(3, 3) will be difficult to settle, by giving machines in these sets for which the halting problem depends on an open problem in number theory. A machine in TM(5, 2) ...

It is frequently stated in the scientific literature, official reports and the press that 80% of Asian and African populations use traditional medicine (TM) to meet their healthcare needs; however, this statistic was first reported in 1983. This study aimed to update knowledge of the prevalence of TM use and the characteristics of those who access it, to inform health policy-makers as countries...

Previous reports demonstrated that the expression of thrombomodulin (TM) in endothelial cells was modulated by various agents. Although TM was down-regulated by endotoxin or cytokines, up-regulation of TM was accomplished when endothelial cells were stimulated with unphysiologically high concentrations of cyclic AMP derivatives or tumour-promoting phorbol esters. We investigated the expression ...

Tamoxifen (Tm)-inducible Cre recombinases are widely used to perform gene inactivation and lineage tracing studies in mice. Although the efficiency of inducible Cre-loxP recombination can be easily evaluated with reporter strains, the precise length of time that Tm induces nuclear translocation of CreER(Tm) and subsequent recombination of a target allele is not well defined, and difficult to as...

Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin interactions. TM is encoded by a family of four alternatively spliced genes that display highly conserved nucleotide and amino acid sequences. To assess the functional and developmental significance of alpha-TM, the murine alpha-TM gene was disrupted by homologous recombina...

AIMS Thrombomodulin (TM), a potent anticoagulant, is not detected in quiescent vascular smooth muscle cells (VSMCs). In diseased vessels, VSMC expresses TM, but the mechanisms are unclear. This study examined molecular mechanisms for TM expression in VSMCs. METHODS AND RESULTS Platelet-derived growth factor-BB (PDGF-BB) induced TM expression in cultured human aortic VSMCs. PDGF-induced TM is ...