BACKGROUND To support age-appropriate growth and to prevent and treat malnutrition in children with cystic fibrosis (CF), energy requirements for those children are often set above the requirements for healthy children. Care providers use one of several empirically derived formulas to calculate energy requirements, yet the validity of these formulas has seldom been tested. OBJECTIVE We evalua...

New biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5-ammino-2-hydroxybenzoic acid (5-ASA) in the main chain were prepared by ter polymerization of methacrylic acid (MA), 2-hydroxyethylmethacrylate (HEMA), and bis (trimethylsilyloxy) methylsilane (VBM) in the presence of some new cross-linking agents.The monomers and polymers were characterized by FT-IR and 1H-NM...

BACKGROUND Claudin-2, ZO-1, and occludin are major components of tight junctions (TJs) in the proximal tubule. However, their roles in maintaining paracellular permeability as leaky epithelia have yet to be defined. METHODS To investigate the contributory role of TJ proteins in the leaky proximal tubule, we xamined the effect of inhibiting claudin-2, occludin, and ZO-1 expression on transepit...

The physiological role of the cellular prion protein (PrP(C)) is incompletely understood. The expression of PrP(C) in hematopoietic stem cells and immune cells suggests a role in the development of these cells, and in PrP(C) knockout animals altered immune cell proliferation and phagocytic function have been observed. Recently, a spontaneous nonsense mutation at codon 32 in the PRNP gene in goa...

Cyclohexylidine-ammonium-2-aminocyclohexyline-l-cyclohexee-l- dithiocarboxylate (CCCD) is employed for the gravimetric determination of Ni (II). In neutral or ammoniacal solutions, the metal forms a violet precipitate with the reagent which can be weighed as Ni (C13H18NS2)a2f ter drying at 115 - 120?C Using this procedure, the nickel content of steel samples can also be determined accurate...

gamma-L-Glutamyl-S-(benzyl)-L-cysteinyl-R-(-)-phenylglycine (TER 117) has previously been developed for selective inhibition of human glutathione S-transferase P1-1 (GST P1-1) based on the postulated contribution of this isoenzyme to the development of drug resistance in cancer cells. In the present investigation, the inhibitory effect of TER 117 on the human glyoxalase system was studied. Alth...

We describe our submission to the NIST Metrics for Machine Translation Challenge consisting of 4 metrics two versions of meteor, m-bleu and m-ter. We first give a brief description of Meteor . That is followed by descriptino of m-bleu and m-ter, enhanced versions of two other widely used metrics bleu and ter, which extend the exact word matching used in these metrics with the flexible matching ...

What controls the dynamics of the transitional ER? Secretory proteins exit from the endoplasmic reticulum (ER) at specialized transitional ER (tER) sites. Benjamin Glick (University of Chicago) described the role of Sec16 in regulating tER organization in the yeast Pichia pastoris. Membrane-associated Sec16 seems to slow ER export. A mutation that redistributes Sec16 to the cytosol relieves thi...

PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit Twente, op gezag van de rector magnificus, prof.dr. de assistent-promotor dr.

Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de