Summary The study aimed to investigate glutathione peroxidase (GPx) activity and (GSH) levels in the sperm of patients with unexplained infertility. samples were collected from subjects normal semen parameters divided into fertile infertile groups. Sperm analysis was performed according 2010 WHO criteria. Measurement GPx GSH by enzymatic assay kits. higher recorded spermatozoa seminal plasma gr...

Screening and identification of tolerant genotypes using osmotic materials under in vitro culture could be rapid, easy, even accurate. In this research, three Iranian landraces Cucurbita sp. included Tanbal Ajili (Cucurbita maxima Duch.), Razan pepo L.), Balghabakhi moschata Duch.) seeds were cultured ¼ MS medium. After germination, plantlets transferred to media containing mannitol PEG 6000. M...

effects of pongamia pinnata, an indigenous plant used in ayurvedic medicine in india on the temporal variations of circulatory lipid peroxidation products and antioxidants in ammonium chloride-(ac)-induced hyperammonemic rats has been studied. experimental rats were divided into control, ac-treated, those treated with ac + ethanolic leaf extract of p. pinnata (ppet), and ppet-treated. the chara...

Melatonin plays several important physiological functions in mammals, such as immune enhancement and regulation of dark-light signal transduction. Melatonin is also known to be an endogenous free radical scavenger and an efficient antioxidant. It detoxifies a variety of free radicals and reactive oxygen intermediates, including the hydroxyl radical, singlet oxygen and nitric oxide. These radica...

NPGPx is a member of the glutathione peroxidase (GPx) family; however, it lacks GPx enzymatic activity due to the absence of a critical selenocysteine residue, rendering its function an enigma. Here, we show that NPGPx is a newly identified stress sensor that transmits oxidative stress signals by forming the disulfide bond between its Cys57 and Cys86 residues. This oxidized form of NPGPx binds ...

Numerous studies indicate a role for oxidative stress in the neuronal degeneration and cell death that occur during ischemia-reperfusion injury. Recent data suggest that inhibition of the proteasome may be a means by which oxidative stress mediates neuronal cell death. In the current study, the authors demonstrate that there is a time-dependent decrease in proteasome activity, which is not asso...

The present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats. Forty male rats were randomly divided into sham, control (I/R injury) and three crocin-pretreated groups. To induce I/R lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. Pretreated-rats re...

We showed previously that the selenium-dependent glutathione peroxidase, GPX-GI, encoded by the Gpx2 gene, is highly expressed in the epithelium of the gastrointestinal (GI) tract and sporadically in breast tissue. To investigate whether Gpx2 gene expression is epithelium specific, we used in situ hybridization to show that Gpx2 mRNA is highly expressed in the crypt epithelium of human intestin...

Cyanobacteria ("blue-green algae") are recognized producers of a diverse array of toxic secondary metabolites. Of these, the lipopolysaccharides (LPS), produced by all cyanobacteria, remain to be well investigated. In the current study, we specifically employed the zebrafish (Danio rerio) embryo to investigate the effects of LPS from geographically diverse strains of the widespread cyanobacteri...

In this study, the oxidative stress effects of cadmium (Cd) toxicity depending on water temperature were investigated Gammarus pulex. The test organism individuals exposed to sublethal concentrations for 96 hours at certain rates (C1; 1/10, C2; 1/20 and C3; 1/40) LC50 values Cd each (10, 14, 18 °C). Malondialdehyde (MDA) level, glutathione peroxidase (GPx), catalase (CAT) enzyme activities temp...