The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming versus the tissue contextual environment for this specialization is not well understood. Here we describe a hierarchy of expression of HOX genes associated with endothelial cell origin and location. In initial microarray studies, differe...

Systemic lupus erythematosus (SLE) is a serious prototype autoimmune disease characterized by chronic inflammation, auto-antibody production and multi-organ damage. Recent association studies have identified a long list of loci that were associated with SLE with relatively high statistical power. However, most of them only established the statistical associations of genetic markers and SLE at t...

Antibody development is still associated with substantial risks and difficulties as single mutations can radically change molecule properties like thermodynamic stability, solubility or viscosity. Since antibody generation methodologies cannot select and optimize for molecule properties which are important for biotechnological applications, careful sequence analysis and optimization is necessar...

BACKGROUND One relatively new and increasingly popular approach of increasing access to treatment is Web-based intervention programs. The advantage of Web-based approaches is the accessibility, affordability, and anonymity of potentially evidence-based treatment. Despite much research evidence on the effectiveness of Web-based interventions for anxiety found in the literature, little is known a...

Increasing healthy food options in public venues, including recreational facilities, is a health priority. The purpose of this study was to describe the public recreation food environment in British Columbia, Canada using a sequential explanatory mixed methods design. Facility audits assessed policy, programs, vending, concessions, fundraising, staff meetings and events. Focus groups addressed ...

Respiratory illnesses are a main source of death in the world and exact lung sound identification is very significant for conclusion assessment sickness. Be that as it may, this method vulnerable to doctors instrument limitations. As result, automated investigation analysis respiratory sounds has been field great research exploration during last decades. The classification potential distinguish...

Neuropathic pain (NP) is caused by damage to the nervous system, resulting in dysfunction and aberrant pain. The cellular functions (e.g., peripheral neuron spinal cord innervation, neuronal excitability) associated with NP often develop over time and are likely associated with gene expression changes. Gene expression studies on the cells involved in NP (e.g., sensory dorsal root ganglion neuro...

Luminescent solar concentrators enhance the power output of cells through wave-guided luminescent emission and have great potential as building-integrated photovoltaics. with a variety geometries absorbing–emitting materials been reported in literature. As breadth available experimental configurations continues to grow, there is an increasing need for versatile Monte Carlo ray-tracing simulatio...

Neural networks are composed of multiple layers arranged in a hierarchical structure jointly trained with gradient-based optimization, where the errors back-propagated from last layer back to first one. At each optimization step, neurons at given receive feedback belonging higher hierarchy. In this paper, we propose complement traditional 'between-layer' additional 'within-layer' encourage dive...