Description 1620 amino acids; 177 kDa; after glycosylation, produces a 200 kDa mature glycoprotein; composed of an extracellular domain, a transmembrane domain, a tyrosine kinase domain, and an intracytoplasmic domain in C-term; dimerization. Expression Is tissue specific; mainly in: brain, gut and testis; not in the lymphocytes. Localisation Cell membrane. Function Membrane associated tyrosine...

ALCL: anaplastic large cell lymphoma CTCL: cutaneous T-cell lymphoma LyP: lymphomatoid papulosis PCALCL: primary cutaneous anaplastic large cell lymphoma RA: rheumatoid arthritis TNF: tumor necrosis factor INTRODUCTION Antietumor necrosis factor (TNF) agents, such as etanercept, infliximab, and adalimumab, are increasingly used in the treatment of many chronic inflammatory diseases, including p...

on chromosome 2p23, and codes for a protein that is expressed in some cells of the central nervous system, but in virtually no other normal human cells. Interest in this protein among diagnostic pathologists has been related to its utility in recognizing a subset of CD30+ anaplastic large cell lymphomas (ALCL's), that show a characteristic t(2;5)(p23;q35) translocation. This translocation resul...

Peripheral T-cell lymphoma, not otherwise specified is a heterogeneous group of aggressive neoplasms with indistinct borders. By gene expression profiling we previously reported unsupervised clusters of peripheral T-cell lymphomas, not otherwise specified correlating with CD30 expression. In this work we extended the analysis of peripheral T-cell lymphoma molecular profiles to prototypical CD30...

Primary bone lymphoma is an uncommon tumour accounting for approximately 4-5% of extra nodal lymphoma and less than 1% of all Non-Hodgkin's lymphoma. The radiographic appearance of primary bone lymphoma is variable. As lesions frequently resemble other disease processes namely chronic osteomyelitis and metastases, further imaging evaluation and histopathological examination allow early identifi...

Anaplastic large cell lymphoma (ALCL) is a rare type of lymphoma T. It represents approximately 1 to 2 % of all cases of non-Hodgkin lymphoma (NHL) in adults. We report the case of a 48 years old male, with no notable medical history, who presented since 12 years a tumor on the right buttock, which gradually increased in size and becoming painful. The dermatological examination revealed a huge ...

We experienced a 58-year-old Korean man with adult T-cell leukemia/lymphoma with features of histologically anaplastic large cell lymphoma involving the skin and testis. The patient had cutaneous nodules in both extremities and a palpable right testicular mass. Right orchiectomy was performed and specimens of removed testicle and skin nodules showed immunohistologically anaplastic large cell ly...