Type I hypersensitivity reactions occur in individuals who have been previously sensitized to a specific allergen. They are the result of allergen recognition by immunoglobulin E on mast cells and basophils and cause a variety of symptoms such as itching or tingling of the lips, tongue or throat; nausea, vomiting and diarrhoea; sneezing, runny nose and wheezing, shortness of breath and coughing...

The concept of elicitation of reactions of anaphylactic type by non-tissue-fixing antibody, through activation of complement and release of anaphylatoxins by antigen-antibody complexes in vivo, is not clearly defined by published evidence. Experimental data are presented to demonstrate that guinea pig immunoglobulin G2 (noncytotropic) complexed with antigen in vitro elicits dermal reactions in ...

Introduction Food is one of the most common causes of anaphylaxis responsible for more than 50-75% of anaphylactic cases in children. Most frequently implicated foods in childhood are milk, egg, nuts, sesame, fish and shellfish worldwide. There are some differences in incidence of types of food allergy in different areas. We tried to describe most common food anaphylactic triggers in patients o...

Background Cofactors may contribute to the elicitation and severity of anaphylaxis in about 30% of anaphylactic reactions. Clinical data from registries can support the identification and risk impact of such cofactors. Besides exercise or alcohol, drugs are known to facilitate anaphylactic reactions. The facilitating effect of cardiovascular drugs to hymenoptera stings is controversially discus...

*Supported in part by the Mr. and Mrs. F. H. Tewksbury grant administered by the San Diego Bio-Chemical Research Institute. 3-13-64 electrocardiographic changes in antigenantibody reactions have been described.34 Electrocardiographic observations of near fatal anaphylactic reactions in the human are sparse. In anaphylactic shock, the most dread of all allergic manifestations, widespread histami...