OBJECTIVES Antimicrobial resistance (AMR) threatens our ability to treat the sexually transmitted bacterial infection gonorrhoea. The increasing availability of whole genome sequence (WGS) data from Neisseria gonorrhoeae isolates, however, provides us with an opportunity in which WGS can be mined for AMR determinants. METHODS Chromosomal and plasmid genes implicated in AMR were catalogued on ...

Antibody-mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. Despite the general acceptance of the usefulness of C4d in the ...

We agree with the recent report in this Journal from Nand and colleagues that education is a key factor in curbing antimicrobial resistance (AMR). AMR is a leading patient health and safety issue that requires engagement at all levels of society. Although there is commitment from clinicians practicing infection-related specialties towards research in AMR and antimicrobial stewardship (AMS), the...

For numerical simulation of detonation, computational cost using uniform meshes is large due to the vast separation in both time and space scales. Adaptive mesh refinement (AMR) is advantageous for problems with vastly different scales. This paper aims to propose an AMR method with high order accuracy for numerical investigation of multi-dimensional detonation. A well-designed AMR method based ...

Transplant rejection is the critical clinical end-point limiting indefinite survival after histocompatibility antigen (HLA) mismatched organ transplantation. The predominant cause of late graft loss is antibody-mediated rejection (AMR), a process whereby injury to the organ is caused by donor-specific antibodies, which bind to HLA and non-HLA (nHLA) antigens. AMR is incompletely diagnosed as do...

OBJECTIVE To compare oral health parameters in perinatally HIV-infected (PHIV) and perinatally HIV-exposed but uninfected youth (PHEU). METHODS In a cross-sectional substudy within the Pediatric HIV/AIDS Cohort Study, participants were examined for number of decayed teeth (DT), Decayed, Missing, and Filled Teeth (DMFT), oral mucosal disease, and periodontal disease (PD). Covariates for oral h...

Originally developed to be used in GSM by the Europe Telecommunications Standards Institute (ETSI), the AMR speech codec [TS 26.071] was approved within the 3GPP forum in 1999 to be mandatory for circuitand packet-switched speech in UMTS networks. An AMR speech codec adapts the error protection level to the local radio channel and traffic conditions so that it always selects the optimum channel...

The National Antimicrobial Resistance Monitoring System (NARMS) was developed approximately 15 years ago to monitor enteric bacteria in humans, food producing animals and retail meats for antimicrobial resistant bacteria (AMR). Included in this program was assessing the quantities and levels of AMR bacteria in samples collected from food producing animals at slaughter plants. While this has pro...

INTRODUCTION Acute antibody-mediated rejection (AMR) in renal-transplant recipients is generally less responsive to conventional antirejection therapy and has a worse prognosis than acute cellular rejection. AREAS COVERED This review provides a broad understanding of the pathogenesis of AMR, recent advances in its therapy, and future directions. Conventional therapeutic approaches to AMR have...

This paper presents a new computer code to solve the general relativistic magnetohydrodynamics (GRMHD) equations using distributed parallel adaptive mesh refinement (AMR). The fluid equations are solved using a finite difference Convex ENO method (CENO) in 3 + 1 dimensions, and the AMR is Berger-Oliger. Hyperbolic divergence cleaning is used to control the ∇ · B = 0 constraint. We present resul...