OBJECTIVES Amoxicillin and clarithromycin have been proven to be effective in the treatment of community-acquired pneumonia. This study investigated the in vivo bactericidal efficacy of a novel, pulsatile dosing strategy for amoxicillin and clarithromycin, when used as monotherapy and combination therapy. METHODS A neutropenic murine pneumonia model was used to assess the bactericidal activit...

only if a = ZFi xi -xi*. We shall derive a somewhat stronger form of this result. We first prove THEOREM 3. Let a be positive. Then the nonzero characteristic roots of Ra are all positive. For we have already shown that we may restrict our attention to the case where = [a]. By hypothesis, 6(xax) > 0 for every x of I, and so we see that 6(xax) = xaSx' = XRaSX' > 0 and the symmetric matrix RaS of...

Clavulanic acid is a potent inhibitor of B-lactamase that is increasingly prescribed in association with amoxicillin. We report 2 cases of patients who experienced pruritus, wheals, and angioedema after oral intake of amoxicillin/clavulanic acid. Routine skin tests for B-lactam antibiotics and specific immunoglobulin (Ig) E were negative in both patients. Analysis of CD63 expression by the baso...

Emerging contaminants are recently uncovered in natural currents duo to human and industrial activities. Most of them have no legal standard can probably cause damaging effects aquatic life at relevant concentrations. The conventional wastewater treatment plant (WWTP) is not always effective for the removal these huge classes pollutants so further water treatments necessary. In this work, we ap...

BACKGROUND Amoxicillin is a commonly used antibiotic which has a short half-life in human. The frequent administration of amoxicillin is often required to keep the plasma drug level in an effective range. The short dosing interval of amoxicillin could also cause some side effects and drug resistance, and impair its therapeutic efficacy and patients' compliance. Therefore, a three-pulse release ...

Lincomycin, chlortetracycline, and amoxicillin are commonly used antimicrobials for growth promotion and infectious disease prophylaxis in swine production. In this study, we investigated the shifts and resistance development among intestinal microbiota in pregnant sows before and after lincomycin, chlortetracycline, and amoxicillin treatment by using phylogenetic analysis, bacterial enumeratio...

INTRODUCTION The Aloysia citriodora plant from the family of Verbenaceae has many uses in traditional medicine. The aim of the current study was to determine the effects of the aqueous and ethanolic extracts of A. citriodora on Streptococcus mutans and Streptococcus sobrinus, which cause tooth decay. METHODS This 2016 study was performed on standardized strains of S. mutans PTCC1683 and S. so...

Infection with Helicobacter pylori is strongly associated with a number of gastroduodenal pathologies. Antimicrobial resistance to commonly-used drugs has generated a considerable interest in the search for novel therapeutic compounds from medicinal plants. As an ongoing effort of this search, the susceptibility of 32 clinical strains of H. pylori and a reference strain-NCTC 11,638-was evaluate...

The antibacterial and anti-inflammatory activities, and protective effects of extracts (flavonoid glycosides) of Polygonum capitatum were investigated to detect the evidence for the utilization of the herb in the clinical therapy of gastritis caused by H. pylori. A mouse gastritis model was established using H. pylori. According to treating methods, model mice were random assigned into a model ...