B-acute lymphoblastic leukemia (B-ALL) is the frequent pediatric malignity. Chemotherapy is the most practical approaches to deal with such malignancies. Microtubule-targeted agents are one of the most strategic drugs which formerly use in chemotherapy.Although,colchicine-binding anti-tubulin agents exhibited promising effects in clinical trials, their exact mechanism of action is not fully und...

Objective(s): This work aimed to assess the effect of 10 new chromon-3-aldehyde derivatives on changes of mitochondrial function under the conditions of brain ischemia in rats. Materials and Methods: The work was executed on BALB/c male-mice (acute toxicity was evaluated) and male Wistar rats, which were used to model cerebral ischemia b...

More and more studies have suggested that methylglyoxal (MGO) induced by type-2 diabetes is related to Parkinson's disease (PD). However, little is known about the molecular mechanism. In this study, we explored the MGO toxicity in neuroblastoma SH-SY5Y cells. Neurotoxicity of MGO was measured by mitochondrial membrane potential, malondialdehyde, and methylthiazoletetrazolium assays. The levels...

Objective(s): Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitoch...

A method is described, based on the differential accumulation of Rb+ and methyltriphenylphosphonium, for the simultaneous estimation of the membrane potentials across the plasma membrane of isolated nerve endings (synaptosomes), and across the inner membrane of mitochondria within the synaptosomal cytoplasm. These determinations, together with measurements of respiratory rates, and ATP and phos...

Emerging line research showed that silk nanoparticles (NPs) have toxicity on the fibroblastand Huvec cells without any toxicity recognized mechanisms. Recently, it suggested peripheralarterial disease confounds almost eight million Americans. Also, due to the main effect offibroblast in a production of extracellular matrix (ECM), adhesive molecules, glycoproteinsand various cytokines, it decide...

Emerging line research showed that silk nanoparticles (NPs) have toxicity on the fibroblastand Huvec cells without any toxicity recognized mechanisms. Recently, it suggested peripheralarterial disease confounds almost eight million Americans. Also, due to the main effect offibroblast in a production of extracellular matrix (ECM), adhesive molecules, glycoproteinsand various cytokines, it decide...

Research on the relationship between mitochondrial membrane potential and fermentation profile is being intensely pursued because of the potential for developing advanced fermentation technologies. In the present study, we isolated naturally occurring strains of yeast from sake mash that produce high levels of malic acid and demonstrate that variations in mitochondrial membrane potential correl...

schizophrenia is a chronic and often debilitating illness which affects about 1% of the world population. some reagents have been used to simulate schizophrenic disorders in laboratory animals, such as amphetamine and ketamine. previous studies have suggested that reactive oxygen species (ros) production, reduced levels of atp, mitochondrial dysfunction and apoptosis are involved in the pathoph...

We have been studying the membranes of cisplatin (DDP)-resistant 2008 human ovarian carcinoma cells (C13* cells) for alterations that may account for their decreased DDP accumulation. We now report that C13* cells have significant changes in their mitochondrial and plasma membrane potentials and in their mitochondrial morphology. C13* cells accumulated 2.0 +/- 0.1-fold more of the membrane pote...