In the title compound, C19H17N5S, the dihedral angles between the purine ring system (r.m.s. deviation = 0.009 Å) and the S-bound and methyl-ene-bound phenyl rings are 74.67 (8) and 71.28 (7)°, respectively. In the crystal, inversion dimers linked by pairs of N-H⋯N hydrogen bonds generate R 2 (2)(8) loops. C-H⋯N inter-actions link the dimers into (100) sheets.

The asymmetric unit of the title compound, C15H17N5, consists of two mol-ecules in which the dihedral angles between the best planes of the purine ring system (r.m.s. deviations = 0.0060 and 0.0190 Å) and the benzene ring are 89.21 (3) and 82.14 (4)°. The mol-ecules within the asymmetric unit are linked into dimers by pairs of N-H⋯N hydrogen bonds. Weak C-H⋯π contacts and π-π inter-actions [cen...

A procedure is presented for the purification of specific mRNAs, which exploits the ability of antibodies prepared against a native protein to bind to the nascent polypeptide on the polysome. Rather than precipitating these soluble antibody-polysome complexes with anti-antibody, which can lead to nonspecific trapping of polysomes, we have linked the anti-antibody to an insoluble matrix. Thus, t...

Fulp et al., “Diphenyl Purine Derivatives as Peripherally Selective Cannabinoid Receptor 1 Antagonists,” Journal of Medicinal Chem istry, 2012, pp. 10022-10032, vol. 55, No. 2. Griffith et al., “Discovery of 1-9-(4-Chlorophenyl)-8-(2chlorophenyl)-9H-purin-6-yl)-4-ethylaminopiperidine-4-carbox ylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor ...

An expeditious and highly efficient single-step methodology for the introduction of a phenylalanine moiety into position 8 and 6 of the purine scaffold was developed based on aqueous-phase Pd-catalysed Suzuki-Miyaura cross-coupling reactions of unprotected 4-boronophenylalanine with 8-bromo- or 6-chloropurines. The scope of the methodology was demonstrated by syntheses of unprotected (adenin-8-...

Asam urat sebagai hasil metabolisme purin dalam tubuh dapat disebabkan oleh kelebihan produksi asam atau terhambatnya eksresi ginjal melalui urine. Seseorang dikategorikan hiperuricemi apabila pada pemeriksaan laboratorium diperoleh kadar di atas 7 mg/dL untuk laki-laki dan 6 perempuan.Tujuan kegiatan pengabdian masyarakat yaitu pembina pengurus Pondok Tahfizul Qur’an As-Syuhada Fi Sabilillah, ...