A melamine-bridged bis-Zn(II) porphyrin dyad covalently attached onto amino-functionalized TentaGel polymer beads or controlled pore glass (CPG) undergoes a reversible and marked colour change from purple to green upon exposure to a biogenic diamine such as cadaverine both in organic and aqueous media.

Enantioselective recognition of amino acids was achieved by using a highly ordered chiral assembly of achiral porphyrin on a chiral molecular gel. Exceptionally high enantioselectivity was observed for histidine derivatives by monitoring the CD patterns and fluorescence quenching, K(SV) (l): 26.3 × 10(3) M(-1); K(SV)(D)-enantiomer: 7.03 × 10(3) M(-1).

Bromhexine hydrochloride ion-selective electrodes (conventional type) based on bromhexinium tetraphenyl borate (I) and bromhexinium-phosphotungstate (II) were prepared. The electrodes exhibited mean slopes of calibration graphs of 59.4 mV and 59.8 mV per decade of bromhexine concentration at 25 C for electrode (I) and (II), respectively. Both electrodes could be used within the concentration ra...

An experimental model for the study of porphyric neuropathy is presented. Injection of either tetraphenyl-porphinesulfonate (TPPS), hematoporphyrin derivative (HpD), or delta-amino-levulinic acid (ALA) into mice resulted in markedly decreased motor nerve conduction velocity (MNCV). THe MNCV returned to normal within one week following the injection of large doses of ALA, and within three weeks ...

Protoporphyrin IX is a naturally occurring amphiphilic porphyrin with a rigid hydrophobic nonpolar core and two polar propionic acid substitutions on the porphyrin ring. This molecule can be modified on the hydrophilic group, which can lead to strengthened π-π-stacking and spontaneous self-assembly into novel nanostructures. Herein, we use l- phenylalanine and d-phenylalanine to modify protopor...

A broad range of applications requires access to porphyrins that are compact, water-soluble, and bioconjugatable. A symmetrically branched hydrocarbon chain ('swallowtail') bearing polar end groups imparts high (>10 mM) aqueous solubility upon incorporation at one of the meso positions of a trans-AB-porphyrin. Two such swallowtail-porphyrins (1a, 1b) equipped with a conjugatable group (carboxyl...