PPARalpha agonists have been characterized largely in terms of their effects on lipids and glucose metabolism, whereas little has been reported about effects on amino acid metabolism. We studied responses to the PPARalpha agonist WY 14,643 (30 micromol x kg(-1) x day(-1) for 4 wk) in rats fed a saturated fat diet. Plasma and urine were analyzed with proton NMR. Plasma amino acids were measured ...

Low concentrations of branched-chain fatty acids, such as isobutyric and isovaleric acids, develop during the ripening of hard cheeses and contribute to the beneficial flavor profile. Catabolism of amino acids, such as branched-chain amino acids, by bacteria via aminotransferase reactions and -keto acids is one mechanism to generate these flavorful compounds; however, metabolism of -keto acids ...

Background and Aims: Amino acids have different effects on the growth of some dermatophytes. Some may increase whereas others maydecrease their growth. The concentration of some amino acids is also an important factor for their effects. Materials and Methods: To investigate the effects of L-amino acids on the growth of six species of dermatophytes including Epidermophyton floccosum, Microspor...

The effects of protein deficiency on the metabolism of ribonucleic acid in the liver have already been described (Munro, Naismith & Wikramanayake, 1953; Clark, Naismith & Munro, 1957). The amount of ribonucleic acid in the liver falls rapidly during the first day of protein depletion and then becomes adjusted at a lower level. During the initial phase of reduction, uptake of 32p and of [14C]gly...

Tumor glucose metabolism and amino acid metabolism are usually enhanced, 18F-FDG for tumor glucose metabolism PET imaging has been clinically well known, but tumor amino acid metabolism PET imaging is not clinically familiar. Radiolabeled amino acids (AAs) are an important class of PET/CT tracers that target the upregulated amino acid transporters to show elevated amino acid metabolism in tumor...

Fetal amino acid nutrition and metabolism have been studied primarily in pregnant sheep. The umbilical uptake of amino acids changes during gestation, but at both mid- and late gestation the total supply exceeds that required for growth. Weight-specific protein synthetic rate decreases with increasing gestational age, and these changes are proportional to the changes in metabolic rate. The use ...

Alterations in sulfur amino acid metabolism are associated with an increased risk of a number of common late-life diseases, which raises the possibility that metabolism of sulfur amino acids may change with age. The present study was conducted to understand the age-related changes in hepatic metabolism of sulfur amino acids in 2-, 6-, 18- and 30-month-old male C57BL/6 mice. For this purpose, me...

In addition to controlled expression of genes by specific regulatory circuits, the abundance proteins and transcripts can also be influenced physiological states cell such as growth rate metabolism. Here we examine control gene metabolism, analyzing a multi-omics dataset consisting absolute-quantitative abundances transcriptome, proteome, amino acids in 22 steady-state yeast cultures. We find t...