Reports suggest a high prevalence of psychological symptoms in alcohol-dependent patients, but there are difficulties in evaluating their significance. To elucidate these relationships, the effect of withdrawal from alcohol on psychological symptoms in men and women detoxifying on an ambulant basis was examined. A prospective study of 65 patients was carried out using a standardized interview w...

Ambulant patients with recently diagnosed generalised or psychomotor seizure disorders or both were randomly assigned to two dosage regimens of phenytoin. Drug compliance was evaluated with subsequent blood phenytoin levels four to eight weeks after initial enrollment into the study. Although the two groups had similar mg-kg daily dosages of phenytoin, the mean blood levels were statistically d...

PURPOSE The aim of this study is to evaluate the feasibility of a telehealthcare application for operable lung cancer (OLC) patients, consisting of ambulant symptom and physical activity monitoring (S&PAM) and a web-accessible home-based exercise program (WEP), and identify possible barriers for successful adoption and implementation. METHODS A two-stage mixed methods design was used, in whic...

BACKGROUND Semi-structured interview scales for psychosis are the gold standard approach to assessing psychotic and other symptoms. However, such assessments have limitations such as recall bias, averaging, insensitivity to change and variable interrater reliability. Ambulant, real-time self-report assessment devices may hold advantages over interview measures, but it needs to be shown that the...

Ambulant continuous intravenous theophylline therapy was used in a patient with frequent and severe asthmatic attacks. The patient could not tolerate oral theophylline preparations. We demonstrated a reduction in complaints and prednisone therapy. Activities of daily life improved, as did theophylline levels, lung function and peak-flow.

Continuous tape recording of the electrocardiogram was carried out on 25 patients with sinus bradycardia or sinoatrial block. A 72-hour record was made on each fully ambulant patient, by a miniature portable tape recorder and the tapes processed with automatic dysrhythmia detection. A high incidence of slow and fast sinaatrial dysrhythmias was discovered and brief episodes of atrial tachydysrhy...

Duchenne muscular dystrophy is a rare genetic disorder with life-limiting pathology. Drisapersen induces exon 51 skipping, thereby producing a shorter but functional dystrophin protein. The longest available data are from an open-label extension study (PRO051-02) treating 12 boys with drisapersen (6 mg/kg/week subcutaneously). The median change (range) from baseline to week 177 in six-minute wa...

OBJECTIVE The aim of this study was to evaluate age-related changes in metabolic walking energy expenditure in ambulant boys affected by Duchenne muscular dystrophy over a follow-up period of 12 months. METHODS At baseline (T1) and 12 months later (T2), metabolic walking energy expenditure was assessed during a 6-minute walk test at comfortable speed in 14 ambulant boys with Duchenne (age ran...