pulmonary arterial hypertension (pah) is a progressive disease with high morbidity and mortality rates. research has shown that pah has a prevalence rate of 10-79% in thalassemia major patients. this cross-sectional study was carried out in 2014 to determine the prevalence and risk factors of pah in all thalassemia major patients of over 18 years of age in ilam, iran. a cardiologist measured sy...

High altitude pulmonary oedema is a life-threatening condition which can affect otherwise healthy individuals travelling at altitude. Common clinical features are breathlessness, chest pain, cough and haemoptysis, and these features often occur against a background of symptoms of mountain sickness, such as headache, nausea, insomnia and dizziness. The incidence of high altitude pulmonary oedema...

We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these circumstances. Pregnant ewes were divided into two groups: conception, pregnancy, and delivery at low altitude (580 m, LLL) and conception at low altitude, pregnancy at HA (3,...

conclusions although we found a trend towards decreasing spah and improving 6mwd, no statistically significant shift were detected in our outcomes due to inadequate sample size. patients and methods a registered (irct201108257411n1), triple-blind, randomized controlled trial was performed in rasoule akram hospital, tehran, from 2009 to 2011. forty five patients with secondary pulmonary hyperten...

hypoxia and hypocapnia can cause broncho-constriction in human subjects, and this could have a bearing on performance at high altitude. the object of this study was to examine how pulmonary ventilatory functions during high-altitude trekking. this study is a cohort study on spirometric parameters at different altitudes. fifty six healthy male volunteers from a university student population were...

Assisted reproductive technologies (ART) predispose the offspring to vascular dysfunction, arterial hypertension, and hypoxic pulmonary hypertension. Recently, cardiac remodeling and dysfunction during fetal and early postnatal life have been reported in offspring of ART, but it is not known whether these cardiac alterations persist later in life and whether confounding factors contribute to th...

• At elevations above 10,000 feet alveolar hypoxia leads to pulmonary arterial hypertension, arterial hypoxemia, and secondary polycythemia in most persons.' The adjustments of adults to this hypoxic environment have been extensively studied but there is relatively little information pertaining to neonates and young children. The only published catheterization study on young children at high al...

introduction pulmonary vein stenosis includes narrowing of one or more pulmonary veins that may have congenital or acquired causes. congenital pulmonary vein stenosis is a rare condition and also a rare cause for pulmonary hypertension. since identifying the etiology of pulmonary hypertension plays a crucial role in medical and surgical planning, we decided to introduce a rare case of pulmonary...

abstract   objective: to evaluate the surgical treatment of total anomalous pulmonary venous connection (tapvc) and determination of predictors for postoperative death. methods: between 1995 and 2005, 80 patients aged from 1 month to 12 years underwent surgical repair for supracardiac (39), cardiac (34), infracardiac (3) or mixed (4) type of tapvc. systemic pulmonary hypertension (ph) in 53.8% ...

Prostacyclin synthase (PGIS) is the final committed enzyme in the metabolic pathway leading to prostacyclin (PGI2) production. Patients with severe pulmonary hypertension have a PGIS deficiency of their precapillary vessels, but the importance of this deficiency for lung vascular remodeling remains unclear. We hypothesized that selective pulmonary overexpression of PGIS may prevent the developm...