Phyteuma globulariifolium is a high alpine plant species growing in the European Alps and the Pyrenees. In order to elucidate its glacial history, 325 individuals from 69 populations were analysed using the amplified fragment length polymorphism (AFLP) technique. A strongly hierarchical phylogeographical pattern was detected: Two major east-west vicariant groups can be separated along a gap in ...

ALPS II is a light shining through a wall style experiment that will use the principle of resonant enhancement to boost the conversion and reconversion probabilities of photons to relativistic WISPs. This will require the use of long baseline low-loss optical cavities. Very high power build up factors in the cavities must be achieved in order to reach the design sensitivity of ALPS II. This nec...

Androsace vitaliana (syn. Vitaliana primuliflora; Primulaceae) has been subject to several taxonomic treatments, whose conclusions ranged from a single species with numerous infraspecific taxa to several species usually without infraspecific taxa. Here, following molecular investigation, several taxonomic changes are made. A single species with the following infraspecific taxa is recognized: su...

Autoimmune lymphoproliferative syndrome (ALPS) represents a failure of apoptotic mechanisms to maintain lymphocyte homeostasis, permitting accumulation of lymphoid mass and persistence of autoreactive cells that often manifest in childhood with chronic nonmalignant lymphadenopathy, hepatosplenomegaly, and recurring multilineage cytopenias. Cytopenias in these patients can be the result of splen...

A polarized gamma ray emission spread over a sufficiently wide energy band from a strongly magnetized astrophysical object like gamma ray bursts (GRBs) offers an opportunity to test the hypothesis of axion like particles (ALPs). Based on evidences of polarized gamma ray emission detected in several gamma ray bursts we estimated the level of ALPs induced dichroism, which could take place in the ...

We present a polynomial-time algorithm that obtains a set of Asymptotic Linear Programs (ALPs) from a given linear system S, such that one of these ALPs admits a feasible solution if and only if S admits a feasible solution. We also show how to use the same algorithm to determine whether or not S admits a non-trivial solution for any desired subset of its variables. S is allowed to consist of l...

Autoimmune lymphoproliferative syndrome (ALPS) is a rare, inherited disorder of immune dysregulation secondary to defective lymphocyte apoptosis. This leads to uninhibited proliferation of lymphoid tissue manifesting with lymphadenopathy, hepatosplenomegaly, autoimmune cytopenia, and an increased risk of lymphoid malignancy. We report a twoyearold boy with fever, generalized lymphadenopathy, he...

Autoimmune lymphoproliferative syndrome (ALPS) is classified among primary immune deficiencies. This prototypic disorder of impaired apoptosis in humans is characterized mainly by autoimmune features and lymphoproliferation. ALPS type 0, caused by homozygous null mutations of the CD95 gene (Fas) leading to a severe ALPS phenotype, is a very rare subgroup with only 3 published cases. Here, we de...

Germline mutations in FASL and FAS impair Fas-dependent apoptosis and cause recessively or dominantly inherited autoimmune lymphoproliferative syndrome (ALPS). Patients with ALPS typically present with no other clinical phenotype. We investigated a large, consanguineous, multiplex kindred in which biological features of ALPS were found in the context of severe bacterial and viral disease, recur...

Ras-associated autoimmune leukoproliferative disorder (RALD) is a nonmalignant clinical syndrome initially identified in a subset of putative autoimmune lymphoproliferative syndrome (ALPS) patients. Similar to patients with ALPS, RALD patients present with lymphadenopathy,massive splenomegaly, increasedcirculatingBcells, hypergammaglobulinemia, and autoimmunity. In contrast to ALPS, biomarkers ...