During the past few years there have been several reports of thalassaemia occurring in English families (Garrett and Morton, 1960; Callender, Mallett, and Lehmann, 1961; Josse, 1962; Roberts, 1963). All the cases, however, have been of the heterozygous form of the disease (thalassaemia minor and thalassaemia trait). This paper reports the case of an English child with homozygous thalassaemia (t...

Both α- and β-thalassaemia syndromes are public health problems in the multi-ethnic population of Malaysia. To molecularly characterise the α- and β-thalassaemia deletions and mutations among Malays from Penang, Gap-PCR and multiplexed amplification refractory mutation systems were used to study 13 α-thalassaemia determinants and 20 β-thalassaemia mutations in 28 and 40 unrelated Malays, respec...

It is easier to diagnose alpha ( oc)-thalass-aemia in neonates, by detecting the presence of haemoglobin (Hb) Bart's because the procedure involved i,.e, haemoglobin electrophoresis for haemoglobin Bart's is inexpensive, rapid and reliable. A study was carried out to find the incidence of Hb, Barts in this part of the world. For this a random collection of cord blood each sample. In addition, e...

BACKGROUND Thalassaemia is a common public health problem in Malaysia and about 4.5 to 6% of the Malays and Chinese are carriers of this genetic disorder. The major forms of thalassaemia result in death in utero of affected foetuses (α-thalassaemia) or life-long blood transfusions for survival in β-thalassaemia. This study, the first nationwide population based survey of thalassaemia in Malaysi...

Genes for thalassaemias, sickle cell disorders and Glucose-6- phosphate dehydrogenase (G6PD) deficiency are known to be associated with prevalent malaria infection. The prevalence in the heterozygote state for sickle cell anaemia (SCA), G6PD and alpha thalassaemia is between 25-30% in Nigerians but the prevalence for the beta thalassaemia trait (BTT) is low. Under-diagnosis of BTT may arise fro...