Cholinergic mechanisms are largely responsible for esophageal contraction in response to swallowing or to in vitro electrical field stimulation (EFS). After induction of experimental esophagitis by repeated acid perfusion, the responses to swallowing and to EFS were significantly reduced but contraction in response to ACh was not affected, suggesting that cholinergic mechanisms are damaged by a...

PURPOSE An investigation into whether alpha(2)-adrenoceptor agonists induce contractions in the porcine ciliary arteries and to characterize the functional receptor subtype mediating these responses. METHODS Isolated arteries from the intraocular part of the porcine ciliary artery were suspended in microvascular myographs for isometric tension recording. The segments were contracted with the ...

In this paper, we established a new class of almost \((\alpha/\eta)\)-\(\psi_\Gamma\)-contraction mapping in induced fuzzy metric space (FMS) and then proved the results for existence fixed point theorem (FPT) multi-valued mappings (MVMs) on collection non-empty closed subsets. application, prove Fredholm integral inclusion (FII). An illustrative example also introduced support our main result.

This study investigated the mechanisms underlying the response to hydrogen peroxide (H(2)O(2)) in mesenteric resistance arteries from spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto (WKY) rats. Arteries were mounted in microvascular myographs for isometric tension recording and for simultaneous measurements of intracellular Ca(2+) concentration ([Ca(2+)](i)), superoxide ani...

Aggregating autologous platelets caused contraction of isolated rings of canine left circumflex arteries. The contractions were augmented after removal of the endothelium and were attenuated by serotonergic antagonists. During contraction caused by prostaglandin F2 alpha, aggregating platelets caused a transient increase in tension followed by a profound relaxation of arteries with endothelium,...

The mechanism of uterine muscle contraction stimulated by a triterpenoid glycoside (dalsaxin) isolated from the root of D. saxatilis was investigated by in vitro methods in the rat. Dalsaxin caused a dose-related increase in uterine muscle contraction. The contraction was single and transient and was abolished by moderate doses of isoprenaline (1.80 nmol-0.40 mumol) and salbutamol (0.13-25 mumo...

In this paper, we introduce the new definitions and fixed-point theorems for \((\hat{\alpha}-\hat{\psi})\)-Geraghty contraction with an aid of simulation function \(\zeta:[0, \infty) \times[0, \rightarrow \mathbb{R}\) in generalized metric space satisfying following condition:if \(\exists \hat{\beta} \in \mathcal{F}\) such that all \(r, s \mathfrak{X}\), then have\(\zeta[\hat{\alpha}(r, s)(d(\m...