OBJECTIVE High-density lipoprotein (HDL) is a heterogeneous lipoprotein class and there is no consensus on the value of HDL subspecies in coronary heart disease (CHD) risk assessment. We tested the hypothesis whether specific HDL subpopulations are significantly associated with CHD-prevalence. METHODS AND RESULTS ApoA-I concentrations (mg/dL) in HDL subpopulations were quantitatively determin...

The solid state track detector of celluloid films (cellulose nitrate+camphor 25% an weight) using etching technique is suitable for low energy alpha particle detection . The critical rate of energy loss for track formation in celluloid films is determined as 1 .3 MeV/mg•Ecm2. Irradiated samples are etched in NaOH (6 N) solution at 46•Ž for 10 minutes . The etched tracks are observed under a vie...

Alpha-particle spectrometry is the most frequently used technique for the activity determination of alpha emitters, such as radium, uranium, plutonium, americium and thorium in environmental samples. In this paper an extensive uncertainty budget is presented for a typical alpha-particle spectrometry measurement of the Ra activity concentration in drinking water. The most influential parameters ...

The stability of proposed ITER scenarios with respect to low-medium mode number Alfvénic instabilities driven by fusion-produced alpha particles is investigated by hybrid MHD-particle simulations. Three cases are considered: the monotonic safety factor scenario (SC2), the reversed-shear one (SC4) and a flat safety factor profile ‘hybrid’ scenario (SCH). All the three cases are found unstable, e...

A systematic study of high energetic alpha particle interaction with microinstability driven turbulence (ITG) is presented. The alpha particles are considered to be passive, thus not modifying the fine structure of the turbulence, and modelled as Maxwellian distributed. Both the turbulent fields and the evolution of the alpha distribution are computed by means of an Eulerian, flux tube code. It...

Radiation-induced cancer of bone, liver, and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High close rates at high LET, effectiveness under hypoxic conditi...

We demonstrate a wide-field alpha-particle imaging system based on the detection of alpha-induced scintillation light from ZnS:Ag screen using an EMCCD camera. develop efficient image processing algorithm to remove cosmic and thermal noise locate alpha particle interactions in images. This is particularly suited low-activity samples where long acquisition periods entail large number frames with...

We investigate the mechanical response of jammed packings repulsive, frictionless spherical particles undergoing isotropic compression. Prior simulations soft-particle model, where repulsive interactions scale as a power-law in interparticle overlap with exponent $\alpha$, have found that ensemble-averaged shear modulus $\langle G \rangle$ increases pressure $P$ $\sim P^{(\alpha-3/2)/(\alpha-1)...

Alpha-particle emitter labeled monoclonal antibodies are being actively developed for treatment of metastatic cancer due to the high linear energy transfer (LET) and the resulting greater biological efficacy of alpha-emitters. Our knowledge of high LET particle radiobiology derives primarily from accelerated heavy ion beam studies. In heavy ion beam therapy of loco-regional tumors, the modulati...