This study was undertaken to localize the enzyme cyclic 3’,5’-adenosine monophosphatase in unstimulated human small lymphocytes. Cyclic AMP may be of importance in mediating lymphocyte stimulation, hence localization of the enzyme that is thought to modulate its intracellular concentration, cyclic AMPase, may point to the site of action of cyclic AMP in the cell. The histochemical technique

.............................................................................................................................. iii FOREWORD ............................................................................................................................. V LIST OF FIGURES ....................................................................................................................

We describe a system of stochastic differential equations (SDEs) which model the interaction between processive molecular motors, such as kinesin and dynein, and the biomolecular cargo they tow as part of microtubule-based intracellular transport. We show that the classical experimental environment fits within a parameter regime which is qualitatively distinct from conditions one expects to fin...

The mechanisms underlying two types of microtubule-dependent nuclear positioning are discussed. 'MTOC-dependent nuclear positioning' occurs when a nucleus is tightly associated with a microtubule organizing center (MTOC). 'Nuclear tracking along microtubules' is analogous to the motor-driven motility of other organelles and occurs when the nucleus lacks an associated MTOC. These two basic types...

In fungi, nuclear pore complexes are free to move through the nuclear envelope; however, little is known about how movement is regulated. New evidence reveals roles for molecular motors and potential impacts on genomic organization.

...................................................................................................................... iii LIST OF TABLES ............................................................................................................ vii LIST OF FIGURES ......................................................................................................... viii CHAPTER