Despite the important role of the antimalarial artesunate and its active metabolite dihydroartemisinin (DHA) in malaria treatment efforts, there are limited data on the pharmacokinetics of these agents in pediatric patients. This study evaluated the effects of body size and gender on the pharmacokinetics of artesunate-DHA using data from pediatric and adult malaria patients. Nonlinear mixed-eff...

Accurate quantification of forest carbon stocks is required for constraining the global carbon cycle and its impacts on climate. The accuracies of forest biomass maps are inherently dependent on the accuracy of the field biomass estimates used to calibrate models, which are generated with allometric equations. Here, we provide a quantitative assessment of the sensitivity of allometric parameter...

25 Despite the important role of the antimalarial artesunate, and its active metabolite 26 dihydroartesmisinin (DHA), in malaria treatment efforts, there are limited data on the 27 pharmacokinetics of these agents in pediatric patients. This study evaluated the effects of body 28 size and gender on the pharmacokinetics of artesunate/DHA using data from pediatric and adult 29 malaria patients. N...

The science of morphological allometry centers around relationships between the size of organismal structures and overall body size. Morphological allometry usually is concerned with two parameters, the slope of log–log plots of trait parameters on body mass or size (reflecting how trait size varies with body size), and the intercept of such plots (providing measures of body-size–independent tr...

Allometry, in general biology, measures the relative growth of a part in relation to the whole living organism. Left ventricular hypertrophy (LVH) is the heart adaptation to excessive load (systolic or diastolic). The increase in left ventricular mass leads to an increase in the electrocardiographic voltages. Based on clinical data, we compared the allometric behavior of three different ECG mar...

Jellyfish form spectacular blooms throughout the world's oceans. Jellyfish body plans are characterised by high water and low carbon contents which enables them to grow much larger than non-gelatinous animals of equivalent carbon content and to deviate from non-gelatinous pelagic animals when incorporated into allometric relationships. Jellyfish have, however, been argued to conform to allometr...

Pharmacopeial recommendations for administration of antimalarial drugs are the same weight-based (mg/kg of body weight) doses for children and adults. However, linear calculations are known to underestimate pediatric doses; therefore, interspecies allometric scaling data may have a role in predicting doses in children. We investigated the allometric scaling relationships of antimalarial drugs u...

The allometric-constraint hypothesis states that evolutionary divergence of morphological traits is restricted by integrated growth regulation. In this study, we test this hypothesis on a time-calibrated and well-documented palaeontological sequence of dental measurements on the Pleistocene arvicoline rodent species Mimomys savini from the Iberian Peninsula. Based on 507 specimens representing ...

The aim of this study was to investigate the influence of MHS genotype on growth and development of muscle and fatty tissue in pig hams. The investigation was performed on 72 barrows divided into 4 groups according to genotype (NN and Nn) and feeding regime (standard and intensive). The data for analyses were collected by MRT imaging; the coefficients of allometric growth were calculated using ...