نتایج جستجو برای: allogeneic transplantation

تعداد نتایج: 151186  

Journal: :international journal of pediatrics 0
ali ghasemi assistant professor of pediatric hematology& oncology, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. for β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...

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2013
Shigeo Fuji Markus Kapp Hermann Einsele

Immune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as in the field of organ transplantation, virus-specific T cells possess crossreactivity potential af...

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Journal: :Haematologica 2011
Matthias Stelljes Dietrich W Beelen Jan Braess Maria C Sauerland Achim Heinecke Björna Berning Hans J Kolb Ernst Holler Rainer Schwerdtfeger Renate Arnold Karsten Spiekermann Carsten Müller-Tidow Hubert L Serve Gerda Silling Wolfgang Hiddemann Wolfgang E Berdel Thomas Büchner Joachim Kienast

UNLABELLED Background Allogeneic hematopoietic cell transplantation is considered the preferred post-remission therapy in patients with acute myeloid leukemia cytogenetically defined as being at high risk. To substantiate evidence for allogeneic hematopoietic cell transplantation in first complete remission in these high-risk patients we performed a landmark analysis within a single prospective...

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Journal: :Blood 2014
Matteo G Della Porta Emilio Paolo Alessandrino Andrea Bacigalupo Maria Teresa van Lint Luca Malcovati Cristiana Pascutto Michele Falda Massimo Bernardi Francesco Onida Stefano Guidi Anna Paola Iori Raffaella Cerretti Paola Marenco Pietro Pioltelli Emanuele Angelucci Rosi Oneto Francesco Ripamonti Paolo Bernasconi Alberto Bosi Mario Cazzola Alessandro Rambaldi

Approximately one-third of patients with myelodysplastic syndrome (MDS) receiving allogeneic hematopoietic stem cell transplantation (HSCT) are cured by this treatment. Treatment failure may be due to transplant complications or relapse. To identify predictive factors for transplantation outcome, we studied 519 patients with MDS or oligoblastic acute myeloid leukemia (AML, <30% marrow blasts) w...

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Journal: :Blood 2002
Susanne Auffermann-Gretzinger Izidore S Lossos Tamara A Vayntrub Wendy Leong F Carl Grumet Karl G Blume Keith E Stockerl-Goldstein Ronald Levy Judith A Shizuru

Regeneration of hematopoiesis after allogeneic hematopoietic cell transplantation (HCT) involves conversion of the recipient's immune system to donor type. It is likely that distinct cell lineages in the recipient reconstitute at different rates. Dendritic cells (DCs) are a subset of hematopoietic cells that function as a critical component of antigen-specific immune responses because they modu...

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Journal: :Blood 2010
Jonathan R Lambert Jamshed B Bomanji Karl S Peggs Kirsty J Thomson Ronjon K Chakraverty Adele K Fielding Panagiotis D Kottaridis Michael Roughton Emma C Morris Anthony H Goldstone David C Linch Peter J Ell Stephen Mackinnon

Allogeneic stem cell transplantation (SCT) is an established therapy for patients with relapsed lymphoma, but the role of positron emission tomography (PET) scanning preallogeneic and postallogeneic SCT is uncertain. We investigated whether pretransplantation PET status predicted outcome after allogeneic SCT and whether PET surveillance after transplantation provided additional information comp...

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Journal: :Seminars in hematology 1998
Fields

Results of conventional or high-dose chemotherapy for peripheral T-cell lymphoma (PTCL) are unsatisfactory, leaving a potential role for autologous or allogeneic stem cell transplantation. There are a number of retrospective studies and a few prospective studies on autologous transplantation for first-line PTCL treatment. Studies show that autologous transplant is feasible in relapsed and previ...

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Journal: :Archives of dermatology 2002
Joan Guitart Scott C Wickless Yu Oyama Timothy M Kuzel Steve T Rosen Ann Traynor Richard Burt

BACKGROUND Allogeneic hematopoietic stem cell transplantation has proved to be an effective therapeutic option in various hematologic neoplastic disorders. Because patients with advanced cutaneous T-cell lymphoma have a poor prognosis, with minimal possibilities of sustained remission, we studied the therapeutic potential of hematopoietic stem cell transplantation. OBSERVATIONS Three young pa...

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2015
Lisa Willemse Sheila Singh

• About Solid Tumours • Cancer Basics • Causes, risk factors and staging • Treatment • How are Stem Cells Helping in the battle against solid tumours? • History of hematopoietic stem cell transplantation (HSCT) • Autologous versus allogeneic HSCT • Allogeneic stem cell transplants – graft versus tumour effect • Autologous HSCT for solid tumours • Research and clinical directions • Hematopoietic...

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2013
Emilio Paolo Alessandrino Matteo G Della Porta Luca Malcovati Christopher H Jackson Cristiana Pascutto Andrea Bacigalupo Maria Teresa van Lint Michele Falda Massimo Bernardi Francesco Onida Stefano Guidi Anna Paola Iori Raffaella Cerretti Paola Marenco Pietro Pioltelli Emanuele Angelucci Rosi Oneto Francesco Ripamonti Alessandro Rambaldi Alberto Bosi Mario Cazzola

Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative treatment for patients with myelodysplastic syndrome (MDS), but involves non-negligible morbidity and mortality. Registry studies have shown that advanced disease stage at transplantation is associated with inferior overall survival. To define the optimal timing of allogeneic HSCT, we carried out a decision a...

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