OBJECTIVE(S) Trichophyton rubrum (T. rubrum) is one of the most common dermatophytes worldwide. This fungus invaded skin appendages of humans and animals. Recently, resistance to antifungal drugs as well as appearance of side effects due to indication of these kinds of antibiotics has been reported. Besides, using some plant extracts have been indicated in herbal medicine as an alternative trea...

The metabolism of diallyl disulfide (DADS), a garlic sulfur compound, was investigated in human liver microsomes. Diallyl thiosulfinate (allicin) was the only metabolite observed and its formation followed Michaelis-Menten kinetics with a Km = 0.61 +/- 0.2 mM and a Vmax = 18.5 +/- 4.2 nmol/min/mg protein, respectively (mean +/- S.E. M., n = 4). Both flavin-containing monooxygenase and the cytoc...

Background: Inflammation is a frequent reaction following therapeutic irradiation. Since the upregulation of adhesion molecules on endothelial cell surface is known to be associated with inflammation, the expression of adhesion molecules is an important therapeutic target. Methods: Treatment of human umbilical endothelial cells (HUVECs) with γ-irradiation (γIR) induces the expression of adhesio...

Background: Methane reduction technology has not yet been put into practical use because of problems such as reduced digestibility, increased costs, additives remaining and microbial adaptations. The objectives this study were to evaluate the effects allicin illite supplementation on ruminal methane production, growth performance carcass characteristics Hanwoo steers. Methods: For in vitro expe...

Bawang putih berasal dari daerah tropis dan subtropis di Asia Tengah menyebar ke bagian lain dunia melalui perdagangan kolonisasi. memiliki sifat farmasi yang tinggi dengan adanya lebih 33 senyawa komponen bioaktif mengandung belerang ampuh menghambat pertumbuhan bakteri, virus, jamur. Kandungan utama dalam umbi bawang adalah allicin sulfur (thio-2-propene-1-sulfinic acid S-allyl ester). Allici...

introduction: the most important virulence factor of brucella is related to its capability of intraphagocytic survival. brucella with this ability,causes persistant infection in host. garlic extract, because of has organosulfur compounds such as allicin, has antimicrobial activity. the aim of this study was to investigate the effect of garlic choloroformic extract on intramacrophage brucella sp...

Background: Liver cancer is associated with a high mortality rate worldwide. Hepatocellular carcinoma (HCC) constitutes large proportion of primary liver cancers, and most its alterations currently remain untreatable. Diallyl trisulfide (DATS), the main chemical constituent allicin, affects tumour development by regulating cell apoptosis. Allicin-induced autophagy could contribute to apoptosis ...

Overdose of acetaminophen causes severe hepatic necrosis in humans and experimental animals. Studies on its hepatotoxicity remain a very active area since some of current data are still uncertain. In this study, freshly isolated rat hepatocytes were used to determine the effects of garlic extract and its component, allicin on the acetaminophen-induced cell cytotoxicity and to compare with the e...

Thiosulfinates (TSs) have been implicated as a principle source of the antiplatelet property of raw onion and garlic juice. The in vitro responses of human platelets to dosages of four TSs were measured using whole blood aggregometry and compared by regression analysis. Of the compounds evaluated, methyl methane-TS (MMTS), propyl propane-TS (PPTS), and 2-propenyl 2-propene-TS (allicin) are pres...

Allicin, one of the active principles of freshly crushed garlic homogenates, has a variety of antimicrobial activities. Allicin in its pure form was found to exhibit i) antibacterial activity against a wide range of Gram-negative and Gram-positive bacteria, including multidrug-resistant enterotoxicogenic strains of Escherichia coli; ii) antifungal activity, particularly against Candida albicans...