I am glad to reply to Goldenberg and Jacob’s observations, whom I thank for the kind attention given to my article. As a preliminary consideration, I wish to reiterate that my paper discussed exclusively the exposure to nickel via food; it didn’t discuss the other routes of systemic exposure. It distinguished allergic contact dermatitis (ACD) from systemic nickel allergy syndrome (SNAS) and, wi...

A Helium-Neon (He-Ne) laser with a wavelength of 632.8 nm is known to have photobiological effects and is widely used for reducing the pain of herpes zoster and accelerating wound healing, however the cellular mechanism and effect of the He-Ne laser are poorly understood. The present study was designed to examine the influence of He-Ne laser irradiation on irritant and allergic contact dermatit...

Allergic contact dermatitis caused by ranitidine is rare. Most cases of allergic contact dermatitis caused by ranitidine have been related to occupational exposure during the pharmaceutical manufacturing process (1–5). We report a case of allergic contact dermatitis caused by ranitidine hydrochloride (HCl) in a veterinary medicament. Interestingly, there have been two recent reports of allergic...

BACKGROUND Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by repeated skin exposure to contact allergens. The severity and duration of this disease are associated with many different factors. Some of these factors may represent markers for monitoring disease activity and the individual response to an intervention. METHODS We used a targeted metabolomics approach to f...

BACKGROUND Spectacle contact allergy is not infrequent. The fine scratches on the spectacle frames which may play a role in the sensitization to the potential allergenic components have not been studied. OBJECTIVE We sought the relationship between the scratches on the spectacle frames and the allergic contact dermatitis (ACD) in the Republic of Korea. METHODS A total of 42 Korean patients ...

Background. The frequency of contact allergens is often regionally different and hence it regional identification is important for the prevention of allergic contact dermatitis (ACD). Objectives. The aim of the study was to determine the most common contact allergens in the etiology of ACD from 2008-2012 and evaluate their dynamics in comparison with similar studies in the Czech Republic and in...

Contact allergy to at least one allergen is common in the European population with a prevalence of 27%. It can develop into allergic contact dermatitis (ACD), which an inflammatory skin condition characterized as delayed-type hypersensitivity reaction manifesting rash and it known that allergen-specific tissue-resident memory CD8+ T (TRM) cells are important development ACD. has been previously...

Epicutaneous patch testing is a well-established diagnostic method for identifying substances that may cause Allergic Contact Dermatitis (ACD), common skin condition caused by exposure to environmental allergens. While the test remains gold standard allergens, it prone observer bias and consumes valuable human resources. Deep learning models can be employed address this challenge. In study, we ...