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M icroenvironment-targeted therapies are emerging as possible complementary approaches to treat malignancies. However, progress is hindered by the complexity of the interactions between malignant cells and their microenvironment. In leukemia, this complexity is further emphasized by a highly dynamic behavior of leukemic cells recently reported in Nature. Hawkins et al. 1 analyze leukemic cell l...
Hadron production at all p T in heavy-ion collisions in the framework of parton re-combination is reviewed. It is shown that the recombination of thermal and shower partons dominates the hadron spectra in the intermediate p T region. In d + Au collisions , the physics of particle production at any η is basically the same as at η = 0. The Cronin effect is described as a result of the final-state...
JOURNAL OF BUSINESS & INDUSTRIAL MARKETING, VOL. 13 NO. 3 1998, pp. 256-270 © MCB UNIVERSITY PRESS, 0885-8624 Introduction The current enthusiasm for “relationship marketing” brings with it a number of problems. In particular this paper will suggest that, unless a counterintuitive definition of a “relationship” is used, it is impossible for firms not to have relationships – indeed that a firm d...
The richest class of t-perfect graphs known so far consists of the graphs with no so-called odd-K4. Clearly, these graphs have the special property that they are hereditary t-perfect in the sense that every subgraph is also t-perfect, but they are not the only ones. In this paper we characterize hereditary t-perfect graphs by showing that any non–t-perfect graph contains a non–tperfect subdivis...
Novel target discovery is warranted to improve treatment in adult T-cell acute lymphoblastic leukemia (T-ALL) patients. We provide a comprehensive study on mutations to enhance the understanding of therapeutic targets and studied 81 adult T-ALL patients. NOTCH1 exhibitedthe highest mutation rate (53%). Mutation frequencies of FBXW7 (10%), WT1 (10%), JAK3 (12%), PHF6 (11%), and BCL11B (10%) were...
Acute lymphoblastic leukemia is the most common malignancy in children. Although it is now curable in 80-90% of cases, patients with T-cell acute lymphoblastic leukemia (T-ALL) experience a higher frequency of induction failure and early relapse. Despite aggressive treatment approaches, including transplantation and new salvage regimens, most children with relapsed T-ALL will not be cured. As s...
A major challenge in the therapy of cancer patients is the development of novel drugs that efficiently target cancerinogenic pathways and replace the highly toxic chemodrugs developed over 50 years ago that nonspecifically eliminate highly proliferative cells. The main goal of discovering new cancer specific drugs is not only to improve the treatment response and cure rate but also to prevent t...
DNA replication ensures accurate duplication of the original genetic information present in a cell in order for it to be properly transmitted to daughter cells. However, replication can be perturbed, for instance in rapidly dividing cancer cells, in a process referred to as replication stress (RS). Checkpoint kinase 1 (CHK1) is an essential component of the ATR-dependent DNA damage-response pat...
Valeria Tosello,1 Marc R. Mansour,2 Kelly Barnes,1 Maddalena Paganin,3 Maria Luisa Sulis,1,4 Sarah Jenkinson,2 Christopher G. Allen,2 Rosemary E. Gale,2 David C. Linch,2 Teresa Palomero,1,5 Pedro Real,1,6 Vundavalli Murty,1 Xiaopan Yao,7 Susan M. Richards,8 Anthony Goldstone,9 Jacob Rowe,10 Giuseppe Basso,3 Peter H. Wiernik,11,12 Elisabeth Paietta,11,12 Rob Pieters,13,14 Martin Horstmann,15,16 ...
To cite: Rajendran R, Patel JS, Singla V, et al. BMJ Case Reports Published online: [please include Day Month Year] doi:10.1136/ bcr-2012-008219 DESCRIPTION A 52year-old man was referred as a case of acute coronary syndrome (ACS) for he had chest pain, vomiting and deep T wave inversions on ECG. Physical examination was normal except for blood pressure of 190/100 mm Hg. ECG (figure 1) satisfied...
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