It has been proposed that the northeastern Tibetan Plateau (NETP) was most recent plateau sub-region to gain elevation, leading profound environmental changes in northern East Asia around mid-Pliocene (ca. 3.6 Ma). Alternatively, region have linked ongoing global cooling and glacial intensification after 3.3 Ma. Here, we test these hypotheses using Plio-Pleistocene estimates of paleotemperature...

Camille Maumet​ 1​ , Tibor Auer​ 2​ , Alexander Bowring​ 1​ , Gang Chen​ 15​, Samir Das​ 3​ , Guillaume Flandin​ 4​ , Satrajit Ghosh​ 5​ , Tristan Glatard​ 3,6​ , Krzysztof J. Gorgolewski​ 7​ , Karl G. Helmer​ 8​ , Mark Jenkinson​ 9​ , David Keator​ 10​ , B. Nolan Nichols​ 11​ , Jean­Baptiste Poline​ 12​ , Richard Reynolds​ 16​, Vanessa Sochat​ 7​ , Jessica Turner​ 13 and T...

We examined the effect of 1-amino-3,5-dimethyladamantane (memantine) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) on the inhibition of [(3)H]MK-801 binding to crude synaptic membranes of rat forebrains in the absence or presence of Ca(2+). Ca(2+) decreased the potency of memantine to inhibit [(3)H]MK-801 binding. The effect of Ca(2+) was apparently competitive w...

We report here new geochronological and paleomagnetic data from the 8022 10 Ma Xiaofeng dykes in South China. Together with existing data, these results suggest that Rodinia probably spread from the equator to the polar region at ca. 800 Ma, followed by a rapid ca. 90‡ rotation around an axis near Greenland that brought the entire supercontinent to a low-latitude position by ca. 750 Ma. We prop...

1 Division of Cardiovascular Medicine and 3 Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women’s Hospital, Boston, MA; Center for Complex Network Research, Northeastern University, Boston, MA; Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA; 5 Center for Cancer Systems Biology, Dana-Farber Cancer Institute,...

1 , B.G. Bills 2,3 , P. Helfenstein 4 , R. Greenberg 5 , G.V. Hoppa 6 and D.P. Hamilton 7 , 1 Planetary Systems Laboratory, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA. 2 Institute for Geophysics and Planetary Physics, Scripps Institution of Oceanography, La Jolla, CA 92093, USA, 3 Jet Propulsion Laboratory, Pasadena, CA 91109, USA. 4 CRSR, Cornell University, Ithaca, NY 14853, U...

In fura 2-loaded N1E-115 cells, regulation of intracellular Ca(2+) concentration ([Ca(2+)](i)) following a Ca(2+) load induced by 1 microM thapsigargin and 10 microM carbonylcyanide p-trifluoromethyoxyphenylhydrazone (FCCP) was Na(+) dependent and inhibited by 5 mM Ni(2+). In cells with normal intracellular Na(+) concentration ([Na(+)](i)), removal of bath Na(+), which should result in reversal...

University of Maryland, College Park, Maryland, 20742, USA (1) Max-Planck-Institut für Plasmaphysik, EURATOM, 85748 Garching, Germany (2) Institute for Fusion Studies, University of Texas, Austin, Texas, 78712 (3) Princeton Plasma Physics Laboratory, Princeton, NJ, 08543 (4) Fusion Research Center, University of Texas, Austin, Texas, 78712 (5) General Atomics, La Jolla, CA (6) Plasma Science an...

Jason Cantarella,1, ∗ Greg Kuperberg,2, † Robert B. Kusner,3, ‡ and John M. Sullivan4, § Department of Mathematics, University of Georgia, Athens, GA 30602 Department of Mathematics, University of California, Davis, CA 95616 Department of Mathematics, University of Massachusetts, Amherst, MA 01003 Department of Mathematics, University of Illinois, Urbana, IL 61801 (Dated: May 5, 2000; revised F...

1 Biofrontiers Institute, University of Colorado, Boulder, CO, USA. 2 Department of Chemistry & Biochemistry, University of Colorado, Boulder, CO, USA. 3 Second Genome, San Bruno, CA, USA. 4 Department of Computer Science, Northern Arizona University, Flagstaff, AZ, USA. 5 Argonne National Laboratory, Argonne, IL, USA. 6 Marine Biological Laboratory, Woods Hole, MA, USA. 7 Howard Hughes Medical...