A homologous series of alkylthio- and alkoxy-based asymmetric calamitic liquid crystal (LC) molecules was developed. The effects alkylthio groups on the phase transition properties unexpected intercalated LC structures were studied.

The synthesis of a series of imidazole styrylindoles and sulfonyl styrylindoles derivatives is described. Evaluation of binding affinity and inhibitory activity against CYP24A1 identified the imidazole styrylindoles as potent inhibitors with activity greater or comparable with the standard ketoconazole. Flexible alignment and docking studies of the inhibitors in the CYP24A1 enzyme active site c...

Several imidazole derivatives bearing titratable charged groups adjacent to the imidazole ring have been studied by nuclear magnetic resonance. Curves relating the chemical shift values of the C-2 and C-4 ring proton resonance signals of these compounds to the solvent pH have been examined. These curves clearly demonstrate effects corresponding to the titration of the neighboring charged groups...

A series of new conjugated compounds with a -SCH₂- linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole-coumarin conjugates, three of them exhibited appealing EC50 values (5.1-8.4 μM) and selective indices >20 against hepatitis C virus. Their potency and selectivity were increased s...

5-Alkylthio-3-methyl-2-thioxo-1,3,4-thiadiazolines have been obtained on heating alkyl 1-methyl-1-hydrazinecarbodithioates with CS(2). A DFT-based computational mechanistic study suggests an initial pseudopericyclic [1,4]H shift as a key step, as well as the intermediacy of the otherwise expected isomers 2-alkylthio-3-methyl-1,3,4-thiadiazolium-5-thiolates, from which the final products are for...

The development of the N-alkylthio-phthalimides is of considerable interest because of the occurrence of many sulfur-containing compounds in many biologically important compounds (Tudge et al. 2006). Stable N-alkylthio-phthalimides have been used to prepare various N-(thioalkyl)amides (Ito et al. 2002; Ito et al. 2003), α-phenylthio-ketones (Wang et al. 2004), disulfides (Wang et al. 2003; Vigu...

Earlier studies (Tamm et al., 1954; Tamm, 1954) showed that benzimidazole derivatives of very high inhibitory activity on influenza and mumps virus multiplication could be produced by multiple substitution of chlorine atoms in the benzenoid ring with ft-D-ribofuranose present at Ni in the imidazole ring. In subsequent reports (Tarm, 1955; Tamm, 1956) evidence was presented to show that the mode...

A very simple annulation reaction was designed, allowing an imidazole moiety to be fused onto a range of pyridine-based derivatives. The methodology consists of an activation step via the formation of a pyridinium salt to increase the electrophilicity of the pyridine ring, followed by a cascade reaction triggered by a nucleophilic attack of the iminium moiety. Depending on the pyridinium salt, ...