The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids in extremely high yields. The reaction conditions are very mild and greener, re...

A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides 10{1,2; 1-12} was prepared by a parallel solution-phase approach. The synthesis comprises a five-step transformation of itaconic acid (11) into 1-methyl and 1-phenyl substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxylic acids 17{1,2} followed by parallel amidation of 17{1,2} with a series of 12 aliphatic a...

The spoilage yeast Saccharomyces cerevisiae degraded the food preservative sorbic acid (2,4-hexadienoic acid) to a volatile hydrocarbon, identified by gas chromatography mass spectrometry as 1,3-pentadiene. The gene responsible was identified as PAD1, previously associated with the decarboxylation of the aromatic carboxylic acids cinnamic acid, ferulic acid, and coumaric acid to styrene, 4-viny...

The dissociation constant pKa defines the ionization degree of organic compounds. It is an important parameter that affects their toxicity and environmental behavior and fate. Among the present approaches to predict pKa values of organic chemicals, increment methods show a good performance but are limited by missing values of special groups. The purpose of this study is to develop models for pr...

A po)ysaccharide flocculant of Klebsiella pneumoniae H12 has been suggested to mediate microbe-plant interactions with the aid of Ca2' [K. Nakata et al., Biosci. BiotechnoL Biochern., 64, 459-465, 2ooOl. Here, twoway regulation of polysaccharide-mediated i"teractions between KL pneumoniae and Ruphanus sativus was studied using organic acids. Namety, 10 mM equiyatents of organic acids promoted p...

The cocrystallization landscape of benzamide and urea interacting with aliphatic and aromatic carboxylic acids was studied both experimentally and theoretically. Ten new cocrystals of benzamide were synthesized using an oriented samples approach via a fast dropped evaporation technique. Information about types of known bi-component cocrystals augmented with knowledge of simple binary eutectic m...

Polyfluoroarenes are an important class of compounds in medical and material chemistry. The synthesis alkylated polyfluoroarenes remains challenging. Here we describe a decarboxylative coupling reaction N-hydroxyphthalimide esters aliphatic carboxylic acids with polyfluoroaryl zinc reagents (Zn-ArF) via synergetic photoredox copper catalysis. This method readily converts primary secondary alkyl...