نتایج جستجو برای: alginate

تعداد نتایج: 8470  

2018
Xiaoyan Zhu Xiangqian Li Hao Shi Jia Zhou Zhongbiao Tan Mengdi Yuan Peng Yao Xiaoyan Liu

Alginate lyases show great potential for industrial and medicinal applications, especially as an attractive biocatalyst for the production of oligosaccharides with special bioactivities. A novel alginate lyase, AlyH1, from the marine bacterium Vibrio furnissii H1, which has been newly isolated from rotten seaweed, was purified and characterized. The purified enzyme showed the specific activity ...

2004
Yuri S. Khotimchenko Maxim Y. Khotimchenko

The purpose of this study was to investigate the pharmacological effects of calcium alginate on carbon tetrachloride (CCL4)-induced hepatotoxicity in rats. The study included two experiments. In the first experiment the animals were given daily CCL4 through gavage for 7 days and then 10, 50, or 250 mg/kg b.w. of calcium alginate for 21 days. The increased bilirubin level, enhanced alanine and a...

Journal: :Journal of materials science. Materials in medicine 2011
Mohammad Kazem Ghahramanpoor Sayed Alireza Hassani Najafabadi Majid Abdouss Fatemeh Bagheri Mohamadreza Baghaban Eslaminejad

Alginate is a family of natural polysaccharides, widely used in industry and medicine for many applications, with its non toxic nature, gentle sol/gel transition procedure and low cost, alginate inferior biomechanical properties have limited its utility especially in tissue engineering. Additionally, ionically cross-linked alginate hydrogels generally lose most of their initial mechanical and s...

2017
Yaxi Chao Shuyan Wang Suqi Wu Jiaqiang Wei Hao Chen

The string of bacteria, Vibrio. sp. QD-5 utilizing alginate, was separated from rotten kelp. The results of genome sequencing showed that the strain QD-5 contained four alginate lyase genes.One of the alginate genes Aly-IV was cloned and linked to the plasmid pET-22b (+). The heterologous expressed alginate lyase aly-IVwas characterized,which possessed the theoretical molecular mass of 62 kDa, ...

2010
Min-Hee Han Jumi Yun Young-Seak Lee Hyung-Il Kim

The alginate-based hydrogel was prepared as a pH-sensitive drug delivery system. To enhance the drug loading capacity, activated carbon was introduced as a drug absorbent. The iron oxide was incorporated into the alginate matrix for the magnetic transferring to the target organ. The activated carbon and iron-oxide were dispersed uniformly in the alginate hydrogel. The drug release from the algi...

2014
Chih-Hui Yang Wei-Ting Wang Alexandru Mihai Grumezescu Keng-Shiang Huang Yung-Sheng Lin

Composite particles with multifunctions have been extensively utilized for various applications. Bubble particles can be applied for ultrasound-mediated imaging, drug delivery, absorbers, cell culture, etc. This study proposes a one-step strategy to obtain Pt nanoparticles loaded in alginate bubbles. A needle-based droplet formation was used to generate uniform alginate particles about 2 mm in ...

2014
Jacinta R. Wiens Adriana I. Vasil Michael J. Schurr Michael L. Vasil

UNLABELLED Pseudomonas aeruginosa strains of non-cystic fibrosis (non-CF) origin do not produce significant amounts of extracellular alginate and are nonmucoid. In CF, such isolates can become mucoid through mutation of one of the genes (mucA, mucB, mucC, or mucD) that produce regulatory factors that sequester AlgU, required for increased expression of alginate genes. Mutation of the muc genes ...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2015
P Woodland F Batista-Lima C Lee S L Preston P Dettmar D Sifrim

Patients with nonerosive reflux disease exhibit impaired esophageal mucosal integrity, which may underlie enhanced reflux perception. In vitro topical application of an alginate solution can protect mucosal biopsies against acid-induced changes in transepithelial electrical resistance (TER). We aimed to confirm this finding in a second model using 3D cell cultures and to assess prolonged protec...

Journal: :International Journal of Nanomedicine 2006
V Manojlovic J Djonlagic B Obradovic V Nedovic B Bugarski

The process of electrostatic extrusion as a method for cell immobilization was investigated that could be used for potential applications in medicine. An attempt was made to assess the effects of cell addition and polymer concentration on the overall entrapment procedure, ie, on each stage of immobilization: polymer-cell suspension rheological characteristics, electrostatic extrusion process, a...

2010
A. B. Jindal M. N. Wasnik Hema A. Nair

Modification of polymers by covalent attachment of thiol bearing pendant groups is reported to impart many beneficial properties to them. Hence in the present study, sodium alginate-cysteine conjugate was synthesized by carbodiimide mediated coupling under varying reaction conditions and the derivatives characterized for thiol content. The thiolated alginate species synthesized had bound thiol ...

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