Adaptive laboratory evolution (ALE) under controlled conditions has become a valuable approach for the study of the genetic and biochemical basis for microbial adaptation under a given selection pressure. Conventionally, the timescale in ALE experiments has been set in terms of number of generations. As mutations are believed to occur primarily during cell division in growing cultures, the cumu...

We present a method for compiling grammars into efficient code for head-driven generation in ALE. Like other compilation techniques already used in ALE, this method integrates ALE's compiled code for logical operations with control-specific information from (SNMP90)'s algorithm along with user-defined directives to identify semantics-related substructures. This combination provides far better p...

In this paper, we propose a new Authenticated Lightweight Encryption algorithm coined ALE. The basic operation of ALE is the AES round transformation and the AES-128 key schedule. ALE is an online single-pass authenticated encryption algorithm that supports optional associated data. Its security relies on using nonces. We provide an optimized low-area implementation of ALE in ASIC hardware and ...

On a growing scale, we use mobile phones for diverse activities in our daily life, for example for entertainment, information or education purposes. In our present research, we assess the feasibility of using a mobile phone to unobtrusively track its user physical activity and the resulting energy expenditure; without of use of any dedicated external device. Activity Level Estimator (ALE) is an...

The Arcade Learning Environment (ALE) is an evaluation platform that poses the challenge of building AI agents with general competency across dozens of Atari 2600 games. It supports a variety of different problem settings and it has been receiving increasing attention from the scientific community, leading to some high-profile success stories such as the much publicized Deep Q-Networks (DQN). I...

Nitric oxide (NO) produced by endothelial nitric-oxide synthase (eNOS) represents an antithrombotic and anti-atherosclerotic principle in the vasculature. Hence, an enhanced expression of eNOS in response to pharmacological interventions could provide protection against cardiovascular diseases. In EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVECs), an arti...

Background Schizochytrium sp. is a marine microalga with great potential as a promising sustainable source of lipids rich in docosahexaenoic acid (DHA). This organism's lipid accumulation machinery can be induced by various stress conditions, but this stress induction usually comes at the expense of lower biomass in industrial fermentations. Moreover, oxidative damage induced by various environ...