Aldosterone exerts an enormous function on proximal tubular cells (PTC) senescence, which is a common pathomechanism contributing to renal dysfunction. Numerous studies have shown that oxidative stress deeply involved in the pathophysiologic processes of chronic kidney diseases. The study aims investigate whether autophagy could regulate process senescence through PTC both vivo and ex vivo. Our...

Although elevated levels of aldosterone are associated with vascular inflammation, the proinflammatory pathways of aldosterone are not completely defined. We now show that aldosterone triggers endothelial cell exocytosis, the first step in leukocyte trafficking. Exogenous aldosterone stimulates endothelial exocytosis of Weibel-Palade bodies, externalizing P-selectin and releasing von Willebrand...

886 The renin–angiotensin–aldosterone system (RAAS) is a dynamic hormonal system. The manner in which the RAAS responds to physiological provocations, such as dietary sodium modulation, characterizes RAAS physiology and abnormalities in RAAS regulation may be associated with cardiometabolic diseases. This is highlighted in the literature that links aldosterone, using single cross-sectional meas...

normotensive hyperaldosteronism is a rare disorder. it is usually diagnosed with hypokalemia or an adrenal mass. our patient was a 27-year-old female presented with weakness. she had normal blood pressure, hypokalemia, high plasma aldosterone level and suppressed plasma renin activity. after the saline load, test aldosterone didn’t show suppression. adrenal computed tomography revealed a left a...

Aldosterone, which plays a key role in maintaining water and electrolyte balance, is produced by zona glomerulosa cells of the adrenal cortex. Autonomous overproduction of aldosterone from zona glomerulosa cells causes primary hyperaldosteronism. Recent clinical studies have highlighted the pathological role of the KCNJ5 potassium channel in primary hyperaldosteronism. Our objective was to dete...

BACKGROUND Aldosterone has been implicated in a variety of organ fibroses, but its role and mechanism in liver fibrosis remain unclear. METHODS Rat primary hepatic stellate cells (HSCs) were isolated, cultured, and characterized. HSCs were incubated with aldosterone (10(-6) M) for 4 h, 8 h, 12 h, 24 h, and 48 h, after which TGF-β1 (transforming growth factor beta 1) expression was measured by...

Primary aldosteronism (PA), the most common form of secondary hypertension, causes relevant morbidity. The value of salivary measurements of aldosterone in clinical routine in PA so far has not been assessed. First, we analyzed salivary and plasma aldosterone concentrations of 42 patients with PA and 37 hypertensive controls (HC) during a sodium infusion test prospectively. Second, morning sali...

BACKGROUND We investigated the environmental and genetic sources of interindividual variability in serum aldosterone level in a large, community-based sample. METHODS We examined the relation of serum aldosterone to vascular risk factors, urine sodium, and candidate single nucleotide polymorphisms in 2891 Framingham Offspring Study participants (53.2% women, mean age 59 years) using multivari...

Aldosterone has been shown to increase cardiac fibrosis in animal and clinical studies in the past 3 decades, and aldosterone treatment has been shown to increase collagen synthesis in rat cardiac fibroblasts and myocardium. In our previous clinical studies, patients with primary aldosteronism (PA), a disease characterized by excessive aldosterone secretion, exhibited increased myocardial fibro...

Blockade of the renin-angiotensin-aldosterone system (RAAS) is being evaluated as a treatment for diabetic retinopathy; however, whether the mineralocorticoid receptor (MR) and aldosterone influence retinal vascular pathology is unknown. We examined the effect of MR antagonism on pathological angiogenesis in rats with oxygen-induced retinopathy (OIR). To determine the mechanisms by which the MR...