نتایج جستجو برای: aldosterone

تعداد نتایج: 11259  

Journal: :Japanese heart journal 1973
T Ito H Hidaka T Kato Y Yoshitoski

This paper shows the result of plasma aldosterone which was measured by radioimmunoassay method using aldosterone-3-carboxymethoxamineBSA or aldosterone-hemisuccinate-BSA. Normal control value at recumbency or upright, primary aldosteronism, uremia, essential hypertension and miscellaneous diseases were examined. By diuretica, plasma aldosterone of normal volunteer was increased but that of pat...

Journal: :Journal of molecular endocrinology 2016
Aurelie Nguyen Dinh Cat Malou Friederich-Persson Anna White Rhian M Touyz

Understanding the mechanisms linking obesity with hypertension is important in the current obesity epidemic as it may improve therapeutic interventions. Plasma aldosterone levels are positively correlated with body mass index and weight loss in obese patients is reported to be accompanied by decreased aldosterone levels. This suggests a relationship between adipose tissue and the production/sec...

Journal: :The Journal of clinical investigation 1983
O B Holland C Thomas H Brown D Schindewolf Y Hillier C Gomez-Sanchez

A dopaminergic mechanism has been proposed to suppress aldosterone secretion. To assess the possibility that a defect in the dopaminergic mechanism might enhance aldosterone secretion in hypertensive patients, we determined basal and adrenocorticotropic hormone (ACTH)-stimulated plasma aldosterone (PA), cortisol, renin activity, and potassium concentrations before and during dopamine receptor s...

Journal: :Circulation 2004
Akiko Mano Tetsuya Tatsumi Jun Shiraishi Natsuya Keira Tetsuya Nomura Mitsuo Takeda Susumu Nishikawa Satoshi Yamanaka Satoaki Matoba Miyuki Kobara Hideo Tanaka Takeshi Shirayama Tetsuo Takamatsu Yoshihisa Nozawa Hiroaki Matsubara

BACKGROUND Aldosterone has recently attracted considerable attention for its involvement in the pathophysiology of heart failure, in which apoptotic cell loss plays a critical role. This study examined whether aldosterone directly induces myocyte apoptosis via its specific receptors. METHODS AND RESULTS Neonatal rat cardiac myocytes were exposed to aldosterone (10(-8) to 10(-5) mol/L). Nuclea...

Journal: :Hypertension research : official journal of the Japanese Society of Hypertension 2004
Atsuhisa Sato Takao Saruta

In recent years, it has been clarified that aldosterone can directly damage various organs, such as the heart, blood vessel, and kidneys, via non-epithelial mineralocorticoid receptors, independent of changes in blood pressure. Anti-aldosterone drugs have been clinically reported to be useful for their organ-protecting effects. The fact that these effects have been considered important for almo...

Journal: :Circulation research 1999
J P Bénitah G Vassort

Aldosterone is associated with the pathogenesis and progression of left ventricular hypertrophy and heart failure, independent of its relation with arterial blood pressure. However, little information exists about the possible influence of this mineralocorticoisteroid on cardiomyocyte electrical activity. The present study was designed to determine the role of aldosterone on whole-cell Ca(2+) c...

Journal: :American journal of physiology. Renal physiology 2007
Hitesh Patni Jayant T Mathew Liming Luan Nicholas Franki Praveen N Chander Pravin C Singhal

Aldosterone has attracted significant consideration for its role in the progression of renal injury. Since apoptotic cell loss contributes to the deterioration of renal function, we examined the effect of aldosterone on tubular cell apoptosis. To determine dose and time course effect, human renal proximal tubular (HK2) cells were treated with aldosterone at different doses and for variable time...

Journal: :The Journal of clinical investigation 2010
Iris Z Jaffe Brenna G Newfell Mark Aronovitz Najwa N Mohammad Adam P McGraw Roger E Perreault Peter Carmeliet Afshin Ehsan Michael E Mendelsohn

In clinical trials, aldosterone antagonists reduce cardiovascular ischemia and mortality by unknown mechanisms. Aldosterone is a steroid hormone that signals through renal mineralocorticoid receptors (MRs) to regulate blood pressure. MRs are expressed and regulate gene transcription in human vascular cells, suggesting that aldosterone might have direct vascular effects. Using gene expression pr...

Journal: :Clinical science 1979
S Abdelhamid P Vecsei D Haack K H Gless D Walb K Lichtwald P Fiegel

1. The determination of aldosterone-18-glucuronide (pH 1-labile aldosterone) was complemented by concomitant measurements of free urinary aldosterone and tetrahydroaldosterone in 307 patients, most of whom were hypertensive. In 38 cases (12.3%) the normal, aldosterone-18-glucuronide concentration was clinically misleading, but increased free aldosterone and/or tetrahydroaldosterone values sugge...

Journal: :Japanese journal of medicine 1989
K Uchida T Kigoshi R Iwasaki S Morimoto

Plasma 18-hydroxycorticosterone (18-OHB) and aldosterone responses to angiotensin II (AII) and ACTH were examined in 2 patients with a 18-OHB-producing tumor (18-OHBPT) versus those in 8 patients with a aldosterone-producing adenoma (APA), 7 patients with low renin essential hypertension (LREH) and 10 normal subjects. Plasma 18-OHB and aldosterone levels and the 18-OHB: aldosterone ratio were h...

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