The meroterpenoids fornicin A, D, and ganodercin found in mushrooms of the Ganoderma genus, have been prepared a concise divergent synthesis route. characteristic unsaturated γ-ketoacid moiety was obtained via an optimized step-wise aldol condensation between two readily accessible building blocks. THP-protection phenolic hydroxyl group under basic conditions developed, protocol that adds to ve...

Nano-graphene oxide was synthesized by the oxidation of graphite powders. The structural nature of the nano-graphene oxide was characterized by a variety of techniques including XRD, TEM, FT-IR and UV/Vis. The functional groups on its basal planes and edges of nano-grahene oxide play important role in catalytic activity. The catalytic activity of nano-graphene oxide was investigated on Crossed-...

An exceptionally stereoselective and general synthesis of (Z)-α-haloacrylates, ready to undergo various synthetic transformations, has been demonstrated from α-haloacetates and aldehydes in a one-pot manner via the titanium-enolate based asymmetric aldol condensation. Besides being an expedient synthetic procedure, the ready availability of diverse α-haloacetates, exceptional stereoselectivity,...

The self-aldol condensation of aldehydes was investigated with rare-earth cations stabilized by [Si]Beta zeolites in parallel bulk metal oxides. Good catalytic performance achieved all Lewis acidic and yttrium appeared to be the best choice. According results several complementary techniques, i.e., temperature-programmed surface reactions, situ diffuse reflectance infrared Fourier transform spe...

A series of 1-(2-chloro-5-nitrophenyl)-3-phenyl-2-propenones were synthesized from 2-chloro-5-nitroacetophenone with various substituted benzaldehydes by crossed-Aldol condensation. The synthesized compounds have been characterized by their physical constants and spectral data. The antimicrobial activities of synthesized 1, 3-diphenyl-2-propenone compounds have been evaluated by Kirby-Baur disc...

Potential of acetates and related compounds in glacial acetic acid as a catalyst for aldol-type condensation reactions was examined. Reactions of cycloalkanones or selected heteroaromatics with aldehydes in presence of 10 mol% of various acetates in acetic acid afforded α,α'-bis(substituted-benzylidene)cycloalkanones and substituted-benzylidene-mackinazolinones, respectively, in good yields. Am...

Two different strategies leading to formal total syntheses of platencin are described. The first strategy involving Claisen rearrangement and radical cyclization provides a rapid access to the core structure of platencin, and also use minimum protective-group operations. The second strategy, a protecting group-free route, utilizes a 6-exo-trig radical cyclization and aldol condensation as key s...

An efficient combination between the Passerini three-component reaction and aldol condensation has been developed for the synthesis of bicyclic isocoumarins with different substituted patterns via solvent-dependent domino pathways. These two operationally friendly methods simultaneously install C-O and C-C bonds in a one-pot manner, allowing the utilization of low-cost and readily accessible 2-...