Transplantation of a human lymphoma to the cheek pouches of unconditioned, adult golden hamsters resulted in permanently transplantable tumors which grow progressively and kill their hosts. This tumor system, GW-478, has a hamster-specific láclate dehydrogenase isoenzyme mobility pattern and both human and hamster glucose 6-phosphate dehyrogenase enzyme profiles when propagated in the hamster ...

BACKGROUND Bone marrow-derived mesenchymal stem cells (BM-MSCs) have potential of differentiation and they secrete anti-inflammatory cytokines and growth factors which make them appropriate for cell therapy. AIM OF THE WORK Were to evaluate the healing effect of BM-MSCs transplantation on germinal cells of busulfan-induced azoospermic hamsters. MATERIAL AND METHODS In the present experiment...

BACKGROUND Recent progress in development of the CRISPR/Cas9 system has been shown to be an efficient gene-editing technology in various organisms. We recently developed a novel method called Genome-editing via Oviductal Nucleic Acids Delivery (GONAD) in mice; a novel in vivo genome editing system that does not require ex vivo handling of embryos, and this technology is newly developed and rena...

Amphotericin B (AmB) has been the first-line treatment for visceral leishmaniasis (VL), a neglected protozoan disease, especially in regions like Bihar, India, where resistance to antimonials is widespread. However, adverse drug reactions are a major limiting factor. We evaluated a novel formulation of AmB conjugated to amine-modified graphene (f-Gr) for safety and efficacy over conventional Am...

We compared tyrosinase cDNA sequences from a line of autosomal albino and Black Silky chickens isolated from cultured melanocytes by reverse transcription-polymerase chain reaction (RT-PCR). Both sources produce a single DNA fragment of predicted normal tyrosinase size. Direct sequencing of the PCR product showed three mutated sites in the tyrosinase gene of the albino chicken. Two silent point...

Albinism is due to a lack of pigmentation in hair, skin and eye, and has been shown to occur in several animal species. Mutations of the tyrosinase (TYR) gene account for albinism in domestic cats, rabbits, cattle, mice and rats. In this study, we demonstrate that a TYR mutation accounts for albinism in the ferret (Mustela putorius furo). The coding sequence of the five exons of TYR was determi...

P. LYMAN. Mikhon& ial oxidative enzymes and phos@iory&ations in cold exposure and hibernation. Am. J. Physiol. 201(1): 29-32. I 96 I .-Oxidative enzyme activities and oxidative phosphorylations of the liver mitochondria of a hibernating species, the golden hamster, and a nonhibernating species, the albino Wistar rat, were examined for changes in response to prolonged cold exposure. Succinic and...

Why was it acceptable for me to utter this sentence, which contains the presuppositional expression my hamster? Presumably it’s because the sentence presupposes that I have a hamster; and a sentence with this presupposition is acceptable in any context like the one we’re in, where you and I come into the conversation sharing the belief that I have a hamster. It could also be that you didn’t kno...

Phlebotomus sergenti is a natural vector of Leishmania tropica. However, the ability of P. sergenti to transmit L. tropica by bite has not been proven experimentally yet. We have transmitted L. tropica to golden hamsters and BALB/c mice by the bite of P. sergenti. Sand flies and Leishmania both originated from an anthroponotic cutaneous leishmaniasis focus in Urfa, Turkey. P. sergenti females f...

A mouse melanoma cDNA clone was isolated by virtue of its reactivity with two antisera raised against tyrosinase (EC 1.14.18.1) from two species, hamster and mouse. The cDNA (5A) cross-hybridizes with another, pMT4 [Shibahara, S., Tomita, V., Sakakura, T., Nager, C., Bhabatosh, C. & Muller, R. (1986) Nucleic Acids Res. 14, 2413-2427], previously thought to encode mouse tyrosinase. Two other cDN...