Purpose: To elucidate the effect of leonurine on proliferation, invasion, migration, and angiogenetic potential breast cancer cells. Methods: Human cell line (MDA-MB-231) normal line, (SK-BR-3) were cultured. Both lines treated with 200, 400, or 800 μM cultured for 0 (control), 24, 48, 72 h. Cell counting kit-8 (CCK8) colony formation assays performed to measure viability proliferation. Invasio...

Identification of the phosphoinositide-3-kinase–protein kinase B/Akt (PI3K-PKB/Akt) pathway and activating receptor tyrosine kinases (RTKs) began in earnest in the early 1980s through vigorous attempts to characterize insulin receptor signaling (for review, see Alessi 2001; Brazil and Hemmings 2001). These humble beginnings led to the identification of the components and mechanism of insulin re...

The phosphatidylinositol 3-kinases (PI3Ks)/protein kinase B (AKT) signaling pathway is frequently overexpressed in lung adenocarcinoma and associated with carcinogenesis through cell proliferation, apoptosis deactivation; it also enhances chemotherapeutic drugs resistance. Tualang honey (TH) has proven anticancer property on adenocarcinoma. However, the underlying mechanisms remain unreported. ...

This study aims to explore the molecular mechanism of neuronal axonal lesions caused by high glucose, and investigate protective effect Lycium barbarum polysaccharide (LBP) on axon damage with in vitro models. A rat model type II diabetic encephalopathy was established, rats were treated LBP for 10 weeks. Morris water maze experiment used detect spatial learning memory ability. Neuronal measure...

BACKGROUND The phosphatidylinositol-3- kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway (PI3K/AKT/mTOR pathway) plays a key role in cancer. We performed this meta-analysis to assess the clinical effect of using PI3K/AKT/mTOR pathway inhibitors on advanced solid tumours. METHODS All the randomised controlled trials (RCT) that compared the therapy with PI3K/AKT/mTOR pathway inhibi...

UNLABELLED The PI3K-AKT signaling pathway regulates all phenotypes that contribute to progression of human cancers, including breast cancer. AKT mediates signal relay by phosphorylating numerous substrates, which are causally implicated in biologic responses such as cell growth, survival, metabolic reprogramming, migration, and invasion. Here a new AKT substrate is identified, the adherens junc...

Abstract Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol a triterpenoid isolated from Ganoderma lucidum known to have various biological functions, including antibacterial effects. However, anti-cancer effects mechanism action lucidadiol in malignant melanoma are unknown. In this study, significantly reduced B16 cell viability dose- time-dependent manner. addition, in...

Purpose: To study the suppressive effect of Hsa-miR-125a-5p on proliferation and invasion cervical cancer (CC) cells through modulation Rab25-PI3K/AKT pathway.Methods: 66 pairs CC neighboring cell samples were harvested from patients who underwent surgical resection in Oncology Department August 2017 to December 2018. The expression levels assessed by quantitative polymerase chain reaction (qPC...

The phosphoinositide 3-kinase and AKT (protein kinase B) signaling pathway (PI3K/AKT) plays a central role in the control of cell survival, growth, and proliferation throughout the body. With regard to bone, and particularly in osteoblasts, there is an increasing amount of evidence that the many signaling molecules exert some of their bone-specific effects in part via selectively activating som...

Correction for ‘Anti-osteosarcoma effect of hydroxyapatite nanoparticles both in vitro and vivo by downregulating the FAK/PI3K/Akt signaling pathway’ Renxian Wang et al., Biomater. Sci., 2020, 8, 4426–4437, DOI: 10.1039/D0BM00898B.