To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-Å structure of the complement component C3–inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement reg...

In order to enhance the performance of interconnects which are used in solid oxide fuel cells (SOFCs), a protective/conductive coating can be applied. In this research AISI 430 ferritic stainless steel was coated in a Mn-base pack mixture by pack cementation method. In order to evaluate the oxidation behavior, isothermal oxidation was accomplished for 200 h at 800 ºC. Electrical behavior was al...

The absorption, metabolism, and excretion of darapladib, a novel inhibitor of lipoprotein-associated phospholipase A2, was investigated in healthy male subjects using [C]-radiolabeled material in a bespoke study design. Disposition of darapladib was compared following single i.v. and both single and repeated oral administrations. The anticipated presence of low circulating concentrations of dru...

In sheet metal forming (SMF), deformation is caused by the relative movement between and tool, which generates friction forces. However, materials behave differently during plastic deformation. this study, a tribo-simulator was designed to investigate effect of different contact conditions or formability tests on tribological behavior AISI 304 430 stainless-steel sheets. The effects texture mic...

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The predominant biosynthetic route to vitamin B6 is catalyzed by a single enzyme. The synthase subunit of this enzyme, Pdx1, operates in concert with the glutaminase subunit, Pdx2, to catalyze the complex condensation of ribose 5-phosphate, glutamine and glyceraldehyde 3-phosphate to form pyridoxal 5¢-phosphate, the active form of vitamin B6. In previous studies it became clear that many if not...

3-n-Butylphthalide (NBP) is a cardiovascular drug currently used for the treatment of cerebral ischemia. The present study aims to investigate the metabolism, pharmacokinetics, and excretion of NBP in humans and identify the enzymes responsible for the formation of major metabolites. NBP underwent extensive metabolism after an oral administration of 200 mg NBP and 23metabolites were identified ...