Objective: To evaluate and compare the protective effects of salbutamol and montelukast in amelioration of insulin induced airway hyper-reactivity on isolated tracheal smooth muscle of guinea pig in vitro. Study Design: Laboratory based randomized control trials (Experimental study). Place and Duration of Study: Pharmacology Department and Centre for Research in Experimental and Applied Medicin...

We assessed the safety and efficacy of combined intravenous and aerosolized antioxidant administration to attenuate chlorine gas-induced airway alterations when administered after exposure. Adult male Sprague-Dawley rats were exposed to air or 400 parts per million (ppm) chlorine (a concentration likely to be encountered in the vicinity of industrial accidents) in environmental chambers for 30 ...

We examined the effects of ozone (O(3)) and endogenous antioxidant transport on canine peripheral airway function, central airway function, epithelial integrity, and inflammation. Dogs were either untreated or pretreated with probenecid (an anion-transport inhibitor) and exposed for 6 h to 0.2 parts/million O(3). Peripheral airway resistance (Rpa) and reactivity (DeltaRpa) were monitored in thr...

BACKGROUND AND PURPOSE Asthma exacerbations contribute to corticosteroid insensitivity. LPS is ubiquitous in the environment. It causes bronchoconstriction and airway inflammation and may therefore exacerbate allergen responses. This study examined whether LPS and ovalbumin co-administration could exacerbate the airway inflammatory and functional responses to ovalbumin in conscious guinea pigs ...

Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma 4 Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma 4 Use of continuous positive airway pressure reduces airway reactivity in adults with asthma 5 A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma 5 Cyclooxygenase-2 inhibi...

We were delighted to read the article in the European Respiratory Journal by HUSSAIN et al. [1] which demonstrated aggravation of pulmonary inflammation and airway hyperreactivity by gold (Au) nanoparticles (NPs) in a mouse model of chemical-induced asthma. Exposure of sensitised (but not unsensitised) mice to Au NPs was shown to result in increased airway resistance and reactivity to methachol...

asthma is a chronic inflammatory disease of the airway with extensive airway remodeling. the ethical issues associated with the studies in asthmatic patients, required development of animal model of asthma. animal models of asthma can provide valuable information on several features of asthma pathogenesis and treatment. although these models cannot carry out all clinical features, they are valu...