BACKGROUND The prevalence of patients with chronic rhinosinusitis (CRS) refractory to traditional therapy appears to be on the increase. In these cases, CRS tends to be associated with bronchial asthma (BA), especially, aspirin-intolerant asthma (AIA). On the other hand, arachidonic acid metabolites have been extensively investigated in the pathogenesis of BA. We sought to assess the role of pr...

Analisou-se o romance distópico O conto de aia, Margaret Atwood, publicado em 1985, observando-se a fragilidade das conquistas do feminismo. A protagonista perde todos os seus direitos e transforma-se uma mera reprodutora. análise foca na constante necessidade lutas feministas pelos mulheres, evidenciando como ainda tenta subverter sua situação pequenos atos resistência. Esta contou com aporte ...

pathway to form the leukotriene, LTA 4 . LTA 4 is an unstable compound and is rapidly metabolized to either LTB 4 or the cysteinyl leukotrienes (CysLTs). The CysLTs are leukocyte chemoattractants and bronchoconstrictors. In addition to COX and 5-LO pathways, 15-lipoxygenase catalyzes the hydroperoxidation of arachidonic acid to form 15-HPETE which is then further metabolized to form 15-HETE and...

Animals have a remarkable ability to track dynamic sensory information. For example, the nematode Caenorhabditis elegans can locate a diacetyl odor source across a 100,000-fold concentration range. Here, we relate neuronal properties, circuit implementation, and behavioral strategies underlying this robust navigation. Diacetyl responses in AWA olfactory neurons are concentration and history dep...

OBJECTIVE Bone loss in arthritis is a complex process characterized by bone erosions and periarticular and generalized bone loss. The antigen-induced arthritis (AIA) model is mainly used to study synovitis and joint destruction, including bone erosions; however, periarticular bone loss has been less extensively investigated. The objectives of this study were to characterize and establish AIA as...

OBJECTIVES Increasing evidence suggests that oxidative stress may play a key role in joint destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that maintains the cellular defence against oxidative stress, in RA. METHODS The activation status of Nrf2 was assessed in synovial ...

OBJECTIVES Synovial fluid glutamate concentrations increase in arthritis. Activation of kainate (KA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. We hypothesised that AMPA and KA GluRs are expressed in human arthritis, and that intra-articular NBQX (AMPA/KA GluR antagonis...

Rheumatoid arthritis (RA) is a chronic inflammatory disease of synovial joints that is associated with cartilage and bone destruction. Death Receptor 3 (DR3), a tumor necrosis factor (TNF) receptor superfamily member, has recently been associated with the pathogenesis of RA. We demonstrate that absence of DR3 confers resistance to the development of adverse bone pathology in experimental antige...

BACKGROUND To validate a questionnaire to assess the activity impairment associated with uncomplicated urinary tract infection (uUTI). METHODS The Activity Impairment Assessment (AIA) assesses the amount of time an individual's work or regular activities have been impaired as a result of their UTI. The measure was completed by 276 women with uUTI who had participated in a prospective, open-la...

BACKGROUND Inflow control prior to transection for right hepatectomy may be achieved either by dissection and ligation of the individual hilar structures outside of the liver (EHD) or by mass stapling of the inflow structures within the hepatic parenchyma. Our preference is for the anterior intrahepatic approach (AIA) with mass stapling, in order to minimise the risk of inadvertent injury of th...