introduction:adenosine as a potent vasodilator has physiological role in regulation of regional cerebral blood flow (rcbf). metod: laser-dِoppler flowmetry technique was used to study pial vessels blood flow responses to adenosine receptors agonists and antagonist. male sprague dawley rats (250-350g) that were housed in standard conditions, were anesthetized with urethane (1.5g/kg). adenosine (g...

5-HT(2A) serotonin receptors represent the principal molecular targets for LSD-like hallucinogens and atypical antipsychotic drugs. It has been proposed that a dysregulation of 5-HT(2A) receptor-mediated signaling may contribute to the pathogenesis of schizophrenia and related diseases. A major mechanism for the attenuation of GPCR signaling following agonist activation typically involves the p...

In article number 2100154, Jun Xu, Adam Procopio, and co-workers have demonstrated a 5 min clinically translatable sonoporation procedure using FDA-approved microbubbles commercially available diagnostic ultrasound enabled the systemic delivery of CDN-based STING agonist MSA-1 regressed both unilaterally bilaterally inoculated syngeneic tumors as result improved PK/PD immune modulation.

BACKGROUND A meta-analysis of the serotonin1A (5-HT1A) receptor partial agonist of the azapirone class as an anxiolytic drug for the treatment of major depressive disorder (MDD) has not previously been reported. METHOD We carried out a systematic review of the literature available in PubMed, the Cochrane Library database and PsycINFO up to 12 October 2013, and conducted a meta-analysis of ran...

5-Hydroxytryptamine 2A (5-HT2A) receptors, a major site of action of clozapine and other atypical antipsychotic medications, are, paradoxically, internalized in vitro and in vivo by antagonists and agonists. The mechanisms responsible for this paradoxical regulation of 5-HT2A receptors are unknown. In this study, the arrestin and dynamin dependences of agonist- and antagonist-mediated internali...

Arif Siddiqui, Saeeda Shaharyar Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi. Pakistan Background: The present study was designed to inves tigate the role of the 5-HT7 receptors in lordosis and release of LH and compare the lordotic responses with 5-HT1A agent. Methods: Ovariectomised but oestradiol benzoate (OB) (10 ug) for 48 h plus by progesterone (0.5 m...

In this study, the relationship between high-affinity agonist binding and second messenger production was examined at native and mutant 5-hydroxytryptamine2A receptors. At native 5-hydroxytryptamine2A receptors all agonists, with the exception of quipazine, discriminated between high- and low-affinity states of the receptor, as determined by analysis of competition binding assays. There was no ...

Abstract Background The effects of vitamin D receptor (VDR) agonist paricalcitol on the podocyte injury induced by high glucose (HG) were investigated in conditioned immortalized mouse podocytes (MPC-5). Methods (1) Grouped according to different concentrations: normal group (NG): 5.6 mmol/L glucose; HG stimulation group: 25 (25HG); osmotic control (NG+M): + 19.4 D-mannitol. expression levels V...